ul_5751----
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PPBD protein
Gene name PTPN6
Synonyms EC 3.1.3.48; Hematopoietic cell protein-tyrosine phosphatase; PTP-1C; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1
GO annotations GO_component: cytoskeleton; membrane [PMID 10506221]
GO_function:hydrolase activity; protein binding [PMID 10660620]; protein tyrosine phosphatase activity [PMID 1732748]
GO_process: apoptosis [PMID 10506221]; G-protein coupled receptor protein signaling pathway [PMID 7781604]; intracellular signaling cascade; protein amino acid dephosphorylation [PMID 1732748]
RefSeq accession NP_002822
SwissProt accession P29350
Substrate protein
Gene name Klrb1b( Description: killer cell lectin-like receptor subfamily B member 1B. )
Synonyms Ly55b; NKR-P1 34; NKR-P1B; Nkrp1-b
GO annotations GO_component: external side of plasma membrane; integral to membrane; integral to plasma membrane; membrane
GO_function:protein binding; protein homodimerization activity; receptor activity; sugar binding
GO_process: negative regulation of natural killer cell mediated cytotoxicity
RefSeq accession NP_032552
SwissProt accession
GO Pathway:
GO:0045953     negative regulation of natural killer cell mediated cytotoxicity
Sequence:(RefSeq accession:NP_032552; substrate region highlighted if known)
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MDSTTLVYAD LNLARIQEPK HDSPPSLSPD TCRCPRWHRL ALKFGCAGLI LLVLVVIGLC
VLVLSVQKSS VQKICADVQE NRTHTTDCSV NLECPQDWLS HRDKCFRVFQ VSNTWEEGQA
DCGRKGATLL LIQDQEELRF LLDSIKEKYN SFWIGLRFTL PDMNWKWING TTFNSDVLKI
TGDTENGSCA SISGDKVTSE SCSTDNRWIC QKELNHETPS NDS
Records:
Category Evidence Reference
A Inference Carlyle JR, Martin A, Mehra A, Attisano L, Tsui FW, Zuniga-Pflucker JC., Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function, [10229828]
End of Record Details