ul_5765----
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PPBD protein
Gene name PTPN6
Synonyms EC 3.1.3.48; Hematopoietic cell protein-tyrosine phosphatase; PTP-1C; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1
GO annotations GO_component: cytoskeleton; membrane [PMID 10506221]
GO_function:hydrolase activity; protein binding [PMID 10660620]; protein tyrosine phosphatase activity [PMID 1732748]
GO_process: apoptosis [PMID 10506221]; G-protein coupled receptor protein signaling pathway [PMID 7781604]; intracellular signaling cascade; protein amino acid dephosphorylation [PMID 1732748]
RefSeq accession NP_002822
SwissProt accession P29350
Substrate protein
Gene name CTNND1( Description: catenin (cadherin-associated protein), delta 1. )
Synonyms CAS; CTNND; Cadherin-associated Src substrate; KIAA0384; P120CAS; P120CTN; p120; p120 catenin; p120(cas); p120(ctn)
GO annotations GO_component: cytoplasm [PMID 9653641]; cytoskeleton; nucleus [PMID 9653641]
GO_function:protein binding; structural molecule activity
GO_process: cell-cell adhesion; regulation of transcription, DNA-dependent; transcription; Wnt receptor signaling pathway
RefSeq accession NP_001322
SwissProt accession O60716
GO Pathway:
GO:0005515     protein binding
Sequence:(RefSeq accession:NP_001322; substrate region highlighted if known)
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MDDSEVESTA SILASVKEQE AQFEKLTRAL EEERRHVSAQ LERVRVSPQD ANPLMANGTL
TRRHQNGRFV GDADLERQKF SDLKLNGPQD HSHLLYSTIP RMQEPGQIVE TYTEEDPEGA
MSVVSVETSD DGTTRRTETT VKKVVKTVTT RTVQPVAMGP DGLPVDASSV SNNYIQTLGR
DFRKNGNGGP GPYVGQAGTA TLPRNFHYPP DGYSRHYEDG YPGGSDNYGS LSRVTRIEER
YRPSMEGYRA PSRQDVYGPQ PQVRVGGSSV DLHRFHPEPY GLEDDQRSMG YDDLDYGMMS
DYGTARRTGT PSDPRRRLRS YEDMIGEEVP SDQYYWAPLA QHERGSLASL DSLRKGGPPP
PNWRQPELPE VIAMLGFRLD AVKSNAAAYL QHLCYRNDKV KTDVRKLKGI PVLVGLLDHP
KKEVHLGACG ALKNISFGRD QDNKIAIKNC DGVPALVRLL RKARDMDLTE VITGTLWNLS
SHDSIKMEIV DHALHALTDE VIIPHSGWER EPNEDCKPRH IEWESVLTNT AGCLRNVSSE
RSEARRKLRE CDGLVDALIF IVQAEIGQKD SDSKLVENCV CLLRNLSYQV HREIPQAERY
QEAAPNVANN TGPHAASCFG AKKGKGKKPI EDPANDTVDF PKRTSPARGY ELLFQPEVVR
IYISLLKESK TPAILEASAG AIQNLCAGRW TYGRYIRSAL RQEKALSAIA DLLTNEHERV
VKAASGALRN LAVDARNKEL IGKHAIPNLV KNLPGGQQNS SWNFSEDTVI SILNTINEVI
AENLEAAKKL RETQGIEKLV LINKSGNRSE KEVRAAALVL QTIWGYKELR KPLEKEGWKK
SDFQVNLNNA SRSQSSHSYD DSTLPLIDRN QKSDNNYSTP NERGDHNRTL DRSGDLGDME
PLKGTTPLMQ DEGQESLEEE LDVLVLDDEG GQVSYPSMQK I
Records:
Category Evidence Reference
A Inference Keilhack H, Hellman U, van Hengel J, van Roy F, Godovac-Zimmermann J, Bohmer FD., The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 catenin, [10835420]
End of Record Details