ul_578----
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PPBD protein
Gene name YWHAH( Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide. )
Synonyms YWHA1
GO annotations GO_component: cytoplasm
GO_function:actin binding; glucocorticoid receptor binding [PMID 9079630]; insulin-like growth factor receptor binding; protein domain specific binding; protein kinase C inhibitor activity; transcriptional activator activity [PMID 15790729]
GO_process: cytoskeleton organization and biogenesis; glucocorticoid catabolism [PMID 15790729]; glucocorticoid receptor signaling pathway [PMID 15790729]; intracellular protein transport; negative regulation of apoptosis; negative regulation of dendrite morphogenesis; negative regulation of protein kinase activity; positive regulation of transcription [PMID 15790729]; regulation of mitosis; regulation of neuron differentiation; regulation of signal transduction; regulation of synaptic plasticity
RefSeq accession NP_003396
SwissProt accession Q04917
Substrate protein
Gene name NRIP1( Description: nuclear receptor interacting protein 1. )
Synonyms Nuclear factor RIP140; RIP140; Receptor-interacting protein 140
GO annotations GO_component: nucleus [PMID 7641693] [PMID 11266503] [PMID 12773562]
GO_function:androgen receptor binding [PMID 15572661]; estrogen receptor binding [PMID 7641693]; glucocorticoid receptor binding [PMID 10364267] [PMID 11266503] [PMID 12773562]; nuclear hormone receptor binding [PMID 11518808]; protein binding [PMID 1266503] [PMID 14736873]; transcription coactivator activity [PMID 7641693] [PMID 10364267] [PMID 11518808] [PMID 15572661]; transcription corepressor activity [PMID 10364267]
GO_process: androgen receptor signaling pathway [PMID 15572661]; negative regulation of transcription from RNA polymerase II promoter [PMID 10364267]; positive regulation of transcription from RNA polymerase II promoter [PMID 7641693] [PMID 10364267]; transcription
RefSeq accession NP_003480
SwissProt accession P48552
Sequence:(RefSeq accession:NP_003480; substrate region highlighted if known)
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MTHGEELGSD VHQDSIVLTY LEGLLMHQAA GGSGTAVDKK SAGHNEEDQN FNISGSAFPT
CQSNGPVLNT HTYQGSGMLH LKKARLLQSS EDWNAAKRKR LSDSIMNLNV KKEALLAGMV
DSVPKGKQDS TLLASLLQSF SSRLQTVALS QQIRQSLKEQ GYALSHDSLK VEKDLRCYGV
ASSHLKTLLK KSKVKDQKPD TNLPDVTKNL IRDRFAESPH HVGQSGTKVM SEPLSCAARL
QAVASMVEKR ASPATSPKPS VACSQLALLL SSEAHLQQYS REHALKTQNA NQAASERLAA
MARLQENGQK DVGSYQLPKG MSSHLNGQAR TSSSKLMASK SSATVFQNPM GIIPSSPKNA
GYKNSLERNN IKQAANNSLL LHLLKSQTIP KPMNGHSHSE RGSIFEESST PTTIDEYSDN
NPSFTDDSSG DESSYSNCVP IDLSCKHRTE KSESDQPVSL DNFTQSLLNT WDPKVPDVDI
KEDQDTSKNS KLNSHQKVTL LQLLLGHKNE ENVEKNTSPQ GVHNDVSKFN TQNYARTSVI
ESPSTNRTTP VSTPPLLTSS KAGSPINLSQ HSLVIKWNSP PYVCSTQSEK LTNTASNHSM
DLTKSKDPPG EKPAQNEGAQ NSATFSASKL LQNLAQCGMQ SSMSVEEQRP SKQLLTGNTD
KPIGMIDRLN SPLLSNKTNA VEENKAFSSQ PTGPEPGLSG SEIENLLERR TVLQLLLGNP
NKGKSEKKEK TPLRDESTQE HSERALSEQI LMVKIKSEPC DDLQIPNTNV HLSHDAKSAP
FLGMAPAVQR SAPALPVSED FKSEPVSPQD FSFSKNGLLS RLLRQNQDSY LADDSDRSHR
NNEMALLESK NLCMVPKKRK LYTEPLENPF KKMKNNIVDA ANNHSAPEVL YGSLLNQEEL
KFSRNDLEFK YPAGHGSASE SEHRSWARES KSFNVLKQLL LSENCVRDLS PHRSNSVADS
KKKGHKNNVT NSKPEFSISS LNGLMYSSTQ PSSCMDNRTF SYPGVVKTPV SPTFPEHLGC
AGSRPESGLL NGCSMPSEKG PIKWVITDAE KNEYEKDSPR LTKTNPILYY MLQKGGNSVT
SRETQDKDIW REASSAESVS QVTAKEELLP TAETKASFFN LRSPYNSHMG NNASRPHSAN
GEVYGLLGSV LTIKKESE
Records:
Category Evidence Reference
A Inference Zilliacus J, Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson JA., Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140., [11266503]
End of Record Details