ul_5863----
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PPBD protein
Gene name PTPN6
Synonyms EC 3.1.3.48; Hematopoietic cell protein-tyrosine phosphatase; PTP-1C; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1
GO annotations GO_component: cytoskeleton; membrane [PMID 10506221]
GO_function:hydrolase activity; protein binding [PMID 10660620]; protein tyrosine phosphatase activity [PMID 1732748]
GO_process: apoptosis [PMID 10506221]; G-protein coupled receptor protein signaling pathway [PMID 7781604]; intracellular signaling cascade; protein amino acid dephosphorylation [PMID 1732748]
RefSeq accession NP_002822
SwissProt accession P29350
Substrate protein
Gene name IL8RB( Description: interleukin 8 receptor, beta. )
Synonyms CD182; CD182 antigen; CDw128b; CMKAR2; CXCR-2; CXCR2; GRO/MGSA receptor; IL-8 receptor type 2; IL-8R B; IL8R2; IL8RA
GO annotations GO_component: cell surface [PMID 10878382]; integral to plasma membrane [PMID 10438939]; intracellular [PMID 10878382]; mast cell granule [PMID 9725262]; membrane [PMID 10725748]
GO_function:interleukin-8 receptor activity [PMID 10820279]; receptor activity; rhodopsin-like receptor activity
GO_process: cellular defense response [PMID 10725748]; chemotaxis [PMID 10725748]; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) [PMID 10438939]; neutrophil activation [PMID 10878382]; neutrophil chemotaxis [PMID 10820279]; positive regulation of cell proliferation [PMID 10438939]
RefSeq accession NP_001548
SwissProt accession P25025
Sequence:(RefSeq accession:NP_001548; substrate region highlighted if known)
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MEDFNMESDS FEDFWKGEDL SNYSYSSTLP PFLLDAAPCE PESLEINKYF VVIIYALVFL
LSLLGNSLVM LVILYSRVGR SVTDVYLLNL ALADLLFALT LPIWAASKVN GWIFGTFLCK
VVSLLKEVNF YSGILLLACI SVDRYLAIVH ATRTLTQKRY LVKFICLSIW GLSLLLALPV
LLFRRTVYSS NVSPACYEDM GNNTANWRML LRILPQSFGF IVPLLIMLFC YGFTLRTLFK
AHMGQKHRAM RVIFAVVLIF LLCWLPYNLV LLADTLMRTQ VIQETCERRN HIDRALDATE
ILGILHSCLN PLIYAFIGQK FRHGLLKILA IHGLISKDSL PKDSRPSFVG SSSGHTSTTL
Records:
Category Evidence Reference
A Inference Sweeney MC, Wavreille AS, Park J, Butchar JP, Tridandapani S, Pei D., Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains, [16274240]
End of Record Details