ul_5865----
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PPBD protein
Gene name PTPN6
Synonyms EC 3.1.3.48; Hematopoietic cell protein-tyrosine phosphatase; PTP-1C; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1
GO annotations GO_component: cytoskeleton; membrane [PMID 10506221]
GO_function:hydrolase activity; protein binding [PMID 10660620]; protein tyrosine phosphatase activity [PMID 1732748]
GO_process: apoptosis [PMID 10506221]; G-protein coupled receptor protein signaling pathway [PMID 7781604]; intracellular signaling cascade; protein amino acid dephosphorylation [PMID 1732748]
RefSeq accession NP_002822
SwissProt accession P29350
Substrate protein
Gene name KIR2DL2( Description: killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2. )
Synonyms CD158B1; CD158b; CD158b1 antigen; MHC class I NK cell receptor; NKAT-6; NKAT6; Natural killer-associated transcript 6; p58 NK receptor; p58 natural killer cell receptor clone CL-43; p58.2
GO annotations GO_component: integral to membrane; integral to plasma membrane; membrane
GO_function:receptor activity
GO_process: immune response
RefSeq accession NP_055034
SwissProt accession P43627
Sequence:(RefSeq accession:NP_055034; substrate region highlighted if known)
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MSLMVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGRLVK SEETVILQCW SDVRFEHFLL
HREGKFKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI
VITGLYEKPS LSAQPGPTVL AGESVTLSCS SRSSYDMYHL SREGEAHECR FSAGPKVNGT
FQADFPLGPA THGGTYRCFG SFRDSPYEWS NSSDPLLVSV IGNPSNSWPS PTEPSSKTGN
PRHLHILIGT SVVIILFILL FFLLHRWCSN KKNAAVMDQE SAGNRTANSE DSDEQDPQEV
TYTQLNHCVF TQRKITRPSQ RPKTPPTDII VYAELPNAES RSKVVSCP
Records:
Category Evidence Reference
A Inference Sweeney MC, Wavreille AS, Park J, Butchar JP, Tridandapani S, Pei D., Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains, [16274240]
End of Record Details