ul_5872----
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PPBD protein
Gene name PTPN6
Synonyms EC 3.1.3.48; Hematopoietic cell protein-tyrosine phosphatase; PTP-1C; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1
GO annotations GO_component: cytoskeleton; membrane [PMID 10506221]
GO_function:hydrolase activity; protein binding [PMID 10660620]; protein tyrosine phosphatase activity [PMID 1732748]
GO_process: apoptosis [PMID 10506221]; G-protein coupled receptor protein signaling pathway [PMID 7781604]; intracellular signaling cascade; protein amino acid dephosphorylation [PMID 1732748]
RefSeq accession NP_002822
SwissProt accession P29350
Substrate protein
Gene name PPAP2A
Synonyms EC 3.1.3.4; PAP-2a; PAP2-alpha; PAP2a; Phosphatidate phosphohydrolase type 2a; Phosphatidic acid phosphatase 2a
GO annotations GO_component: integral to plasma membrane [PMID 9705349]; membrane fraction [PMID 9468526]; plasma membrane [PMID 9705349]
GO_function:hydrolase activity; phosphatidate phosphatase activity [PMID 9468526] [PMID 9570154]
GO_process: androgen receptor signaling pathway [PMID 9468526]; germ cell migration [PMID 9305923]; negative regulation of cell proliferation [PMID 9468526]; phospholipid dephosphorylation [PMID 9468526]; protein kinase C activation [PMID 9468526]; regulation of lipid metabolism [PMID 9468526]
RefSeq accession NP_003702
SwissProt accession O14494
Sequence:(RefSeq accession:NP_003702; substrate region highlighted if known)
1
61
121
181
241
MFDKTRLPYV ALDVLCVLLA GLPFAILTSR HTPFQRGVFC NDESIKYPYK EDTIPYALLG
GIIIPFSIIV IILGETLSVY CNLLHSNSFI RNNYIATIYK AIGTFLFGAA ASQSLTDIAK
YSIGRLRPHF LDVCDPDWSK INCSDGYIEY YICRGNAERV KEGRLSFYSG HSSFSMYCML
FVALYLQARM KGDWARLLRP TLQFGLVAVS IYVGLSRVSD YKHHWSDVLT GLIQGALVAI
LVAVYVSDFF KERTSFKERK EEDSHTTLHE TPTTGNHYPS NHQP
Records:
Category Evidence Reference
A Inference Sweeney MC, Wavreille AS, Park J, Butchar JP, Tridandapani S, Pei D., Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains, [16274240]
End of Record Details