ul_5879----
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PPBD protein
Gene name PTPN6
Synonyms EC 3.1.3.48; Hematopoietic cell protein-tyrosine phosphatase; PTP-1C; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1
GO annotations GO_component: cytoskeleton; membrane [PMID 10506221]
GO_function:hydrolase activity; protein binding [PMID 10660620]; protein tyrosine phosphatase activity [PMID 1732748]
GO_process: apoptosis [PMID 10506221]; G-protein coupled receptor protein signaling pathway [PMID 7781604]; intracellular signaling cascade; protein amino acid dephosphorylation [PMID 1732748]
RefSeq accession NP_002822
SwissProt accession P29350
Substrate protein
Gene name MCTP2
Synonyms
GO annotations GO_component: integral to membrane [PMID 15528213]; membrane fraction [PMID 15528213]
GO_function:calcium ion binding [PMID 15528213]; calcium-dependent phospholipid binding [PMID 15528213]
GO_process: calcium-mediated signaling [PMID 15528213]
RefSeq accession NP_060819
SwissProt accession
Sequence:(RefSeq accession:NP_060819; substrate region highlighted if known)
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MDLDKPSVWG SLKQRTRPLL INLSKKKVKK NPSKPPDLRA RHHLDRRLSL SVPDLLEAEA
LAPEGRPYSG PQSSYTSVPS SLSTAGIFPK SSSSSLKQSE EELDWSQEEA SHLHVVETDS
EEAYASPAER RRVSSNGIFD LQKTSLGGDA PEEPEKLCGS SDLNASMTSQ HFEEQSVPGE
ASDGLSNLPS PFAYLLTIHL KEGRNLVVRD RCGTSDPYVK FKLNGKTLYK SKVIYKNLNP
VWDEIVVLPI QSLDQKLRVK VYDRDLTTSD FMGSAFVILS DLELNRTTEH ILKLEDPNSL
EDDMGVIVLN LNLVVKQGDF KRHRWSNRKR LSASKSSLIR NLRLSESLKK NQLWNGIISI
TLLEGKNVSG GSMTEMFVQL KLGDQRYKSK TLCKSANPQW QEHFDFHYFS DRMGILDIEV
WGKDNKKHEE RLGTCKVDIS ALPLKQANCL ELPLDSCLGA LLMLVTLTPC AGVSVSDLCV
CPLADLSERK QITQRYCLQN PLKDVKDVGI LQVKVLKAAD LLAADFSGKS DPFCLLELGN
DRLQTHTVYK NLNPEWNKVF TFPIKDIHDV LEVTVFDEDG DKPPDFLGKV AIPLLSIRDG
QPNCYVLKNK DLEQAFKGVI YLEMDLIYNP VKASIRTFTP REKRFVEDSR KLSKKILSRD
VDRVKRITMA IWNTMQFLKS CFQWESTLRS TIAFAVFLIT VWNFELYMIP LALLLIFVYN
FIRPVKGKVS SIQDSQESTD IDDEEDEDDK ESEKKGLIER IYMVQDIVST VQNVLEEIAS
FGERIKNTFN WTVPFLSSLA CLILAAATII LYFIPLRYII LIWGINKFTK KLRNPYSIDN
NELLDFLSRV PSDVQKVQYA ELKLCSSHSP LRKKRSAL
Records:
Category Evidence Reference
A Inference Sweeney MC, Wavreille AS, Park J, Butchar JP, Tridandapani S, Pei D., Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains, [16274240]
End of Record Details