ul_5995----
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PPBD protein
Gene name PTPN6
Synonyms EC 3.1.3.48; Hematopoietic cell protein-tyrosine phosphatase; PTP-1C; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1
GO annotations GO_component: cytoskeleton; membrane [PMID 10506221]
GO_function:hydrolase activity; protein binding [PMID 10660620]; protein tyrosine phosphatase activity [PMID 1732748]
GO_process: apoptosis [PMID 10506221]; G-protein coupled receptor protein signaling pathway [PMID 7781604]; intracellular signaling cascade; protein amino acid dephosphorylation [PMID 1732748]
RefSeq accession NP_002822
SwissProt accession P29350
Substrate protein
Gene name SIGLEC7
Synonyms AIRM-1; Adhesion inhibitory receptor molecule 1; CD328 antigen; CDw328; D-siglec; QA79 membrane protein; Siglec-7; p75
GO annotations GO_component: integral to plasma membrane [PMID 10567377]; membrane
GO_function:protein binding; receptor activity [PMID 10499918]; sugar binding [PMID 10567377]
GO_process: cell adhesion
RefSeq accession NP_055200
SwissProt accession Q9Y286
Sequence:(RefSeq accession:NP_055200; substrate region highlighted if known)
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MLLLLLLPLL WGRERVEGQK SNRKDYSLTM QSSVTVQEGM CVHVRCSFSY PVDSQTDSDP
VHGYWFRAGN DISWKAPVAT NNPAWAVQEE TRDRFHLLGD PQTKNCTLSI RDARMSDAGR
YFFRMEKGNI KWNYKYDQLS VNVTALTHRP NILIPGTLES GCFQNLTCSV PWACEQGTPP
MISWMGTSVS PLHPSTTRSS VLTLIPQPQH HGTSLTCQVT LPGAGVTTNR TIQLNVSYPP
QNLTVTVFQG EGTASTALGN SSSLSVLEGQ SLRLVCAVDS NPPARLSWTW RSLTLYPSQP
SNPLVLELQV HLGDEGEFTC RAQNSLGSQH VSLNLSLQQE YTGKMRPVSG VLLGAVGGAG
ATALVFLSFC VIFIVVRSCR KKSARPAADV GDIGMKDANT IRGSASQGNL TESWADDNPR
HHGLAAHSSG EEREIQYAPL SFHKGEPQDL SGQEATNNEY SEIKIPK
Records:
Category Evidence Reference
A Inference Sweeney MC, Wavreille AS, Park J, Butchar JP, Tridandapani S, Pei D., Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domains, [16274240]
End of Record Details