ul_601----
Record details: Hide
PPBD protein
Gene name YWHAH( Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide. )
Synonyms YWHA1
GO annotations GO_component: cytoplasm
GO_function:actin binding; glucocorticoid receptor binding [PMID 9079630]; insulin-like growth factor receptor binding; protein domain specific binding; protein kinase C inhibitor activity; transcriptional activator activity [PMID 15790729]
GO_process: cytoskeleton organization and biogenesis; glucocorticoid catabolism [PMID 15790729]; glucocorticoid receptor signaling pathway [PMID 15790729]; intracellular protein transport; negative regulation of apoptosis; negative regulation of dendrite morphogenesis; negative regulation of protein kinase activity; positive regulation of transcription [PMID 15790729]; regulation of mitosis; regulation of neuron differentiation; regulation of signal transduction; regulation of synaptic plasticity
RefSeq accession NP_003396
SwissProt accession Q04917
Substrate protein
Gene name PDPK1( Description: 3-phosphoinositide dependent protein kinase-1. )
Synonyms EC 2.7.11.1; MGC20087; MGC35290; PDK1; PRO0461; PkB-like; PkB-like 1; hPDK1
GO annotations GO_component: cytoplasm [PMID 9637919]; plasma membrane [PMID 9637919]
GO_function:3-phosphoinositide-dependent protein kinase activity [PMID 9368760]; ATP binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity; transferase activity
GO_process: actin cytoskeleton organization and biogenesis [PMID 10792047]; insulin receptor signaling pathway [PMID 10792047]; protein amino acid phosphorylation [PMID 9368760]
RefSeq accession NP_002604
SwissProt accession O15530
GO Pathway:
GO:0006469     negative regulation of protein kinase activity
Sequence:(RefSeq accession:NP_002604; substrate region highlighted if known)
1
61
121
181
241
301
361
421
481
541
MARTTSQLYD AVPIQSSVVL CSCPSPSMVR TQTESSTPPG IPGGSRQGPA MDGTAAEPRP
GAGSLQHAQP PPQPRKKRPE DFKFGKILGE GSFSTVVLAR ELATSREYAI KILEKRHIIK
ENKVPYVTRE RDVMSRLDHP FFVKLYFTFQ DDEKLYFGLS YAKNGELLKY IRKIGSFDET
CTRFYTAEIV SALEYLHGKG IIHRDLKPEN ILLNEDMHIQ ITDFGTAKVL SPESKQARAN
SFVGTAQYVS PELLTEKSAC KSSDLWALGC IIYQLVAGLP PFRAGNEYLI FQKIIKLEYD
FPEKFFPKAR DLVEKLLVLD ATKRLGCEEM EGYGPLKAHP FFESVTWENL HQQTPPKLTA
YLPAMSEDDE DCYGNYDNLL SQFGCMQVSS SSSSHSLSAS DTGLPQRSGS NIEQYIHDLD
SNSFELDLQF SEDEKRLLLE KQAGGNPWHQ FVENNLILKM GPVDKRKGLF ARRRQLLLTE
GPHLYYVDPV NKVLKGEIPW SQELRPEAKN FKTFFVHTPN RTYYLMDPSG NAHKWCRKIQ
EVWRQRYQSH PDAAVQ
Records:
Category Evidence Reference
A Mutagenesis Sato S, Fujita N, Tsuruo T., Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3., [12177059]
End of Record Details