ul_6077----
Record details: Hide
PPBD protein
Gene name RASA1
Synonyms GAP; GTPase-activating protein; Ras p21 protein activator; RasGAP; p120GAP
GO annotations GO_component: cytoplasm [PMID 2821624]; intracellular
GO_function:GTPase binding [PMID 2122974]; potassium channel inhibitor activity [PMID 1553544]; Ras GTPase activator activity [PMID 2188736]; receptor binding [PMID 2157284] [PMID 2176151]
GO_process: actin cytoskeleton organization and biogenesis; cell adhesion; cytokinesis; embryonic development; intracellular signaling cascade [PMID 1581965]; negative regulation of cell adhesion [PMID 8344248]; negative regulation of cell-matrix adhesion [PMID 8344248]; negative regulation of neuron apoptosis; positive regulation of anti-apoptosis [PMID 15542850]; regulation of actin filament polymerization [PMID 8344248]; regulation of cell shape [PMID 9113414]; regulation of RNA metabolism [PMID 9113414]; regulation of small GTPase mediated signal transduction; vasculogenesis
RefSeq accession NP_002881
SwissProt accession P20936
Substrate protein
Gene name Ephb2( Description: Eph receptor B2. )
Synonyms Cek5; Drt; ETECK; Erk; Hek5; Nuk; Prkm5; Qek5; Sek3; Tyro5
GO annotations GO_component: integral to membrane; integral to plasma membrane; membrane; synapse
GO_function:ATP binding; axon guidance receptor activity; ephrin receptor activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein-tyrosine kinase activity; receptor activity; receptor binding; transferase activity; transmembrane-ephrin receptor activity
GO_process: axon guidance; learning; organ morphogenesis; positive regulation of long-term neuronal synaptic plasticity; protein amino acid phosphorylation; regulation of axonogenesis; regulation of neuronal synaptic plasticity; transmembrane receptor protein tyrosine kinase signaling pathway
RefSeq accession NP_034272
SwissProt accession
GO Pathway:
GO:0007411     axon guidance
Sequence:(RefSeq accession:NP_034272; substrate region highlighted if known)
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
MAVRRLGAAL LLLPLLAAVE ETLMDSTTAT AELGWMVHPP SGWEEVSGYD ENMNTIRTYQ
VCNVFESSQN NWLRTKFIRR RGAHRIHVEM KFSVRDCSSI PSVPGSCKET FNLYYYEADF
DLATKTFPNW MENPWVKVDT IAADESFSQV DLGGRVMKIN TEVRSFGPVS RNGFYLAFQD
YGGCMSLIAV RVFYRKCPRI IQNGAIFQET LSGAESTSLV AARGSCIANA EEVDVPIKLY
CNGDGEWLVP IGRCMCKAGF EAVENGTVCR GCPSGTFKAN QGDEACTHCP INSRTTSEGA
TNCVCRNGYY RADLDPLDMP CTTIPSAPQA VISSVNETSL MLEWTPPRDS GGREDLVYNI
ICKSCGSGRG ACTRCGDNVQ YAPRQLGLTE PRIYISDLLA HTQYTFEIQA VNGVTDQSPF
SPQFASVNIT TNQAAPSAVS IMHQVSRTVD SITLSWSQPD QPNGVILDYE LQYYEKELSE
YNATAIKSPT NTVTVQGLKA GAIYVFQVRA RTVAGYGRYS GKMYFQTMTE AEYQTSIKEK
LPLIVGSSAA GLVFLIAVVV IAIVCNRRGF ERADSEYTDK LQHYTSGHMT PGMKIYIDPF
TYEDPNEAVR EFAKEIDISC VKIEQVIGAG EFGEVCSGHL KLPGKREIFV AIKTLKSGYT
EKQRRDFLSE ASIMGQFDHP NVIHLEGVVT KSTPVMIITE FMENGSLDSF LRQNDGQFTV
IQLVGMLRGI AAGMKYLADM NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDTSDPTY
TSALGGKIPI RWTAPEAIQY RKFTSASDVW SYGIVMWEVM SYGERPYWDM TNQDVINAIE
QDYRLPPPMD CPSALHQLML DCWQKDRNHR PKFGQIVNTL DKMIRNPNSL KAMAPLSSGI
NLPLLDRTIP DYTSFNTVDE WLEAIKMGQY KESFANAGFT SFDVVSQMMM EDILRVGVTL
AGHQKKILNS IQVMRAQMNQ IQSVEV
Records:
Category Evidence Reference
A Peptide library Holland SJ, Gale NW, Gish GD, Roth RA, Songyang Z, Cantley LC, Henkemeyer M, Yancopoulos GD, Pawson T., Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells, [9233798]
End of Record Details