ul_6085----
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PPBD protein
Gene name RASA1
Synonyms GAP; GTPase-activating protein; Ras p21 protein activator; RasGAP; p120GAP
GO annotations GO_component: cytoplasm [PMID 2821624]; intracellular
GO_function:GTPase binding [PMID 2122974]; potassium channel inhibitor activity [PMID 1553544]; Ras GTPase activator activity [PMID 2188736]; receptor binding [PMID 2157284] [PMID 2176151]
GO_process: actin cytoskeleton organization and biogenesis; cell adhesion; cytokinesis; embryonic development; intracellular signaling cascade [PMID 1581965]; negative regulation of cell adhesion [PMID 8344248]; negative regulation of cell-matrix adhesion [PMID 8344248]; negative regulation of neuron apoptosis; positive regulation of anti-apoptosis [PMID 15542850]; regulation of actin filament polymerization [PMID 8344248]; regulation of cell shape [PMID 9113414]; regulation of RNA metabolism [PMID 9113414]; regulation of small GTPase mediated signal transduction; vasculogenesis
RefSeq accession NP_002881
SwissProt accession P20936
Substrate protein
Gene name EPHB2( Description: EPH receptor B2. )
Synonyms CAPB; DRT; EC 2.7.10.1; EPHT3; ERK; Hek5; MGC87492; PCBC; Receptor protein-tyrosine kinase HEK5; Renal carcinoma antigen NY-REN-47; Tyro5; Tyrosine-protein kinase TYRO5; Tyrosine-protein kinase receptor EPH-3
GO annotations GO_component: integral to membrane; membrane; synapse
GO_function:ATP binding; ephrin receptor activity; nucleotide binding; protein binding; protein-tyrosine kinase activity; receptor activity; transferase activity; transmembrane-ephrin receptor activity [PMID 8589679]
GO_process: nervous system development [PMID 8589679]; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
RefSeq accession NP_004433
SwissProt accession P29323
GO Pathway:
GO:0007399     nervous system development
Sequence:(RefSeq accession:NP_004433; substrate region highlighted if known)
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MALRRLGAAL LLLPLLAAVE ETLMDSTTAT AELGWMVHPP SGWEEVSGYD ENMNTIRTYQ
VCNVFESSQN NWLRTKFIRR RGAHRIHVEM KFSVRDCSSI PSVPGSCKET FNLYYYEADF
DSATKTFPNW MENPWVKVDT IAADESFSQV DLGGRVMKIN TEVRSFGPVS RSGFYLAFQD
YGGCMSLIAV RVFYRKCPRI IQNGAIFQET LSGAESTSLV AARGSCIANA EEVDVPIKLY
CNGDGEWLVP IGRCMCKAGF EAVENGTVCR GCPSGTFKAN QGDEACTHCP INSRTTSEGA
TNCVCRNGYY RADLDPLDMP CTTIPSAPQA VISSVNETSL MLEWTPPRDS GGREDLVYNI
ICKSCGSGRG ACTRCGDNVQ YAPRQLGLTE PRIYISDLLA HTQYTFEIQA VNGVTDQSPF
SPQFASVNIT TNQAAPSAVS IMHQVSRTVD SITLSWSQPD QPNGVILDYE LQYYEKELSE
YNATAIKSPT NTVTVQGLKA GAIYVFQVRA RTVAGYGRYS GKMYFQTMTE AEYQTSIQEK
LPLIIGSSAA GLVFLIAVVV IAIVCNRRRG FERADSEYTD KLQHYTSGHM TPGMKIYIDP
FTYEDPNEAV REFAKEIDIS CVKIEQVIGA GEFGEVCSGH LKLPGKREIF VAIKTLKSGY
TEKQRRDFLS EASIMGQFDH PNVIHLEGVV TKSTPVMIIT EFMENGSLDS FLRQNDGQFT
VIQLVGMLRG IAAGMKYLAD MNYVHRDLAA RNILVNSNLV CKVSDFGLSR FLEDDTSDPT
YTSALGGKIP IRWTAPEAIQ YRKFTSASDV WSYGIVMWEV MSYGERPYWD MTNQDVINAI
EQDYRLPPPM DCPSALHQLM LDCWQKDRNH RPKFGQIVNT LDKMIRNPNS LKAMAPLSSG
INLPLLDRTI PDYTSFNTVD EWLEAIKMGQ YKESFANAGF TSFDVVSQMM MEDILRVGVT
LAGHQKKILN SIQVMRAQMN QIQSVEV
Records:
Category Evidence Reference
A Mutagenesis Holland SJ, Gale NW, Gish GD, Roth RA, Songyang Z, Cantley LC, Henkemeyer M, Yancopoulos GD, Pawson T., Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells, [9233798]
End of Record Details