ul_6105----
Record details: Hide
PPBD protein
Gene name RASA1
Synonyms GAP; GTPase-activating protein; Ras p21 protein activator; RasGAP; p120GAP
GO annotations GO_component: cytoplasm [PMID 2821624]; intracellular
GO_function:GTPase binding [PMID 2122974]; potassium channel inhibitor activity [PMID 1553544]; Ras GTPase activator activity [PMID 2188736]; receptor binding [PMID 2157284] [PMID 2176151]
GO_process: actin cytoskeleton organization and biogenesis; cell adhesion; cytokinesis; embryonic development; intracellular signaling cascade [PMID 1581965]; negative regulation of cell adhesion [PMID 8344248]; negative regulation of cell-matrix adhesion [PMID 8344248]; negative regulation of neuron apoptosis; positive regulation of anti-apoptosis [PMID 15542850]; regulation of actin filament polymerization [PMID 8344248]; regulation of cell shape [PMID 9113414]; regulation of RNA metabolism [PMID 9113414]; regulation of small GTPase mediated signal transduction; vasculogenesis
RefSeq accession NP_002881
SwissProt accession P20936
Substrate protein
Gene name Cd5( Description: CD5 antigen. )
Synonyms MGC114334
GO annotations GO_component: external side of plasma membrane; immunological synapse; integral to membrane; integral to plasma membrane; plasma membrane
GO_function:glycoprotein binding; protein binding
GO_process: cell proliferation; cell recognition; induction of apoptosis by extracellular signals; regulation of lymphocyte proliferation; regulation of signal transduction; T cell costimulation
RefSeq accession NP_062168
SwissProt accession
GO Pathway:
GO:0009966     regulation of signal transduction
Sequence:(RefSeq accession:NP_062168; substrate region highlighted if known)
1
61
121
181
241
301
361
421
481
MDSHEVLLAA TYLLGTLAAF CLGQSGRGFV GAQVMLSGSN SKCQGLVEVQ MNGMKTVCSS
SWRLSQDLWK NANEASTVCQ QLGCGNPLAL GHLTLWNRPK NQILCQGPPW SFSNCSTSSL
GQCLPLSLVC LEPQKTTPLP TTTLPTTMPE PTAPPRLQLV PGHEGLRCTG VVEFYNGSRG
GTILYKAKAR PVDLGNLICK SLQCGSFLTH LSRIETAGTP APAELRDPRP LPIRWEAQNG
SCTSLQQCFQ KTTVQEGSQA LAVVCSDFQP KVQSRLVGGS SVCEGIAEVR QRSQWAALCD
SSAARGPGRW EELCQEQQCG NLISFHVMDA DRTSPGVLCT QEKLSQCYQL QKKTHCKRVF
ITCKDPNPVG LAPGTVASII LTLVLLVVLM VMCGPLIYKK LVKKFRQKKQ RQWIGPTGVN
QSMSFHRSHT ATVRSQVENP AASHVDNEYS QPPRNSRLSA YPALEGALHR SSTQPDNSSD
SDYDLQVAQR L
Records:
Category Evidence Reference
A Peptide library Dennehy KM, Broszeit R, Ferris WF, Beyers AD., Thymocyte activation induces the association of the proto-oncoprotein c-cbl and ras GTPase-activating protein with CD5, [9603468]
End of Record Details