ul_614----
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PPBD protein
Gene name YWHAH( Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide. )
Synonyms YWHA1
GO annotations GO_component: cytoplasm
GO_function:actin binding; glucocorticoid receptor binding [PMID 9079630]; insulin-like growth factor receptor binding; protein domain specific binding; protein kinase C inhibitor activity; transcriptional activator activity [PMID 15790729]
GO_process: cytoskeleton organization and biogenesis; glucocorticoid catabolism [PMID 15790729]; glucocorticoid receptor signaling pathway [PMID 15790729]; intracellular protein transport; negative regulation of apoptosis; negative regulation of dendrite morphogenesis; negative regulation of protein kinase activity; positive regulation of transcription [PMID 15790729]; regulation of mitosis; regulation of neuron differentiation; regulation of signal transduction; regulation of synaptic plasticity
RefSeq accession NP_003396
SwissProt accession Q04917
Substrate protein
Gene name SNCA
Synonyms NACP; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor
GO annotations GO_component: cytoplasm [PMID 8248242]
GO_function:protein binding [PMID 11956199]
GO_process: anti-apoptosis [PMID 10818098]; central nervous system development [PMID 9197268]
RefSeq accession NP_000336
SwissProt accession P37840
Sequence:(RefSeq accession:NP_000336; substrate region highlighted if known)
1
61
121
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK
EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP
DNEAYEMPSE EGYQDYEPEA
Records:
Category Evidence Reference
A Mutagenesis Sato S, Chiba T, Sakata E, Kato K, Mizuno Y, Hattori N, Tanaka K., 14-3-3eta is a novel regulator of parkin ubiquitin ligase., [16096643]
End of Record Details