ul_618----
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PPBD protein
Gene name YWHAH( Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide. )
Synonyms YWHA1
GO annotations GO_component: cytoplasm
GO_function:actin binding; glucocorticoid receptor binding [PMID 9079630]; insulin-like growth factor receptor binding; protein domain specific binding; protein kinase C inhibitor activity; transcriptional activator activity [PMID 15790729]
GO_process: cytoskeleton organization and biogenesis; glucocorticoid catabolism [PMID 15790729]; glucocorticoid receptor signaling pathway [PMID 15790729]; intracellular protein transport; negative regulation of apoptosis; negative regulation of dendrite morphogenesis; negative regulation of protein kinase activity; positive regulation of transcription [PMID 15790729]; regulation of mitosis; regulation of neuron differentiation; regulation of signal transduction; regulation of synaptic plasticity
RefSeq accession NP_003396
SwissProt accession Q04917
Substrate protein
Gene name Numbl( Description: numb-like. )
Synonyms
GO annotations GO_component: cytoplasm
GO_function:protein binding
GO_process: axonogenesis; forebrain development; nervous system development; neuroblast proliferation
RefSeq accession NP_001029060
SwissProt accession Q3MUI2
Sequence:(RefSeq accession:NP_001029060; substrate region highlighted if known)
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MSRSAAASGG PRRPDQHLPP APCGASGPPE TFRTESDGAG TMNKLRQSLR RRKPAYVPEA
SRPHQWQADE DAVRKGTCSF PVRYLGHVEV EESRGMHVCE DAVKKLKAMG RKSVKSVLWV
SADGLRVVDD KTKDLLVDQT IEKVSFCAPD RNLDKAFSYI CRDGTTRRWI CHCFLALKDS
GERLSHAVGC AFAACLERKQ RREKECGVTA AFDASRTSFA REGSFRLSGG GRPAEREAGD
KKKEAAAAPA VAPGPAQPGH VSPTPATTSP GEKGEAGTPV AAGTTAAAIP RRHAPLEQLV
RQGSFRGFPA LSQKNSPFKR QLSLRLNELP STLQRRTDFQ VKGTVPEMEP PGTGDSDGIS
ALCTQISSSF ASAGAPVPGP PSATTGTSAW GEPSVPAATA FQPGHKRTPS EAERWLEEVS
QVAKAQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQATSVPP MPTMAPTLQP FSAPVGPFDT
AAAQVAVFLP PTHMQPPFVP AYPGLGYPPM PRVPVVGITP SQMVANAFCS AAQLQPQPAT
LLGKAGAFPP PTAPSAPGGQ ARPRPNGAPW PPEPAPAPAP ELDPFEAQWA ALEGKPAVEK
PSNPFSGDLQ KTFEIEL
Records:
Category Evidence Reference
A Mutagenesis Tokumitsu H, Hatano N, Inuzuka H, Sueyoshi Y, Yokokura S, Ichimura T, Nozaki N, Kobayashi R., Phosphorylation of Numb family proteins. Possible involvement of Ca2+/calmodulin-dependent protein kinases., [16105844]
End of Record Details