ul_6206----
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PPBD protein
Gene name SH2D1A( Description: SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome). )
Synonyms DSHP; Duncan disease SH2-protein; EBVS; IMD5; LYP; MTCP1; SAP; SLAM-associated protein; Signaling lymphocyte activation molecule-associated protein; T-cell signal transduction molecule SAP; XLP; XLPD
GO annotations GO_component: cytoplasm [PMID 9774102]
GO_function:SH3/SH2 adaptor activity [PMID 9774102]
GO_process: cell-cell signaling [PMID 9774102]; cellular defense response [PMID 9774102]; intracellular signaling cascade
RefSeq accession NP_002342
SwissProt accession O60880
Substrate protein
Gene name SLAMF1( Description: signaling lymphocytic activation molecule family member 1. )
Synonyms CD150; CD150 antigen; CDw150; IPO-3; SLAM
GO annotations GO_component: cell surface; integral to membrane; membrane
GO_function:antigen binding [PMID 7617038]; receptor activity; transmembrane receptor activity [PMID 7617038]
GO_process: antimicrobial humoral response (sensu Vertebrata) [PMID 7617038]; lymphocyte activation; positive regulation of cell proliferation [PMID 7617038]
RefSeq accession NP_003028
SwissProt accession Q13291
Sequence:(RefSeq accession:NP_003028; substrate region highlighted if known)
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MDPKGLLSLT FVLFLSLAFG ASYGTGGRMM NCPKILRQLG SKVLLPLTYE RINKSMNKSI
HIVVTMAKSL ENSVENKIVS LDPSEAGPPR YLGDRYKFYL ENLTLGIRES RKEDEGWYLM
TLEKNVSVQR FCLQLRLYEQ VSTPEIKVLN KTQENGTCTL ILGCTVEKGD HVAYSWSEKA
GTHPLNPANS SHLLSLTLGP QHADNIYICT VSNPISNNSQ TFSPWPGCRT DPSETKPWAV
YAGLLGGVIM ILIMVVILQL RRRGKTNHYQ TTVEKKSLTI YAQVQKPGPL QKKLDSFPAQ
DPCTTIYVAA TEPVPESVQE TNSITVYASV TLPES
Records:
Category Evidence Reference
A Structure Poy F, Yaffe MB, Sayos J, Saxena K, Morra M, Sumegi J, Cantley LC, Terhorst C, Eck MJ., Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition, [10549287]
End of Record Details