ul_6267----
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PPBD protein
Gene name SH2D2A( Description: SH2 domain protein 2A. )
Synonyms F2771; SH2 domain-containing adapter protein; T cell-specific adapter protein; TSAd; VEGF receptor-associated protein
GO annotations GO_component: cytoplasm [PMID 9468509]; soluble fraction [PMID 9468509]
GO_function:protein binding [PMID 10553045]; SH3/SH2 adaptor activity [PMID 9468509]
GO_process: angiogenesis; cell differentiation; intracellular signaling cascade
RefSeq accession NP_003966
SwissProt accession Q9NP31
Substrate protein
Gene name VCP( Description: valosin-containing protein. )
Synonyms 15S Mg(2+)-ATPase p97 subunit; IBMPFD; MGC131997; MGC148092; MGC8560; TER ATPase; TERA; VCP; Valosin-containing protein; p97
GO annotations GO_component: cytosol [PMID 10855792] [PMID 15215856]; endoplasmic reticulum [PMID 15215856]; microsome; nucleus [PMID 10855792] [PMID 16130169]
GO_function:ATP binding [PMID 15215856]; ATPase activity [PMID 15215856]; hydrolase activity; lipid binding; nucleotide binding; protein binding [PMID 10855792] [PMID 15215856] [PMID 15743842] [PMID 16449189]
GO_process: caspase activation; double-strand break repair [PMID 10855792]; ER-associated protein catabolism [PMID 15215856]; establishment of protein localization [PMID 15215856]; protein ubiquitination [PMID 15215856]; regulation of apoptosis [PMID 16130169]; retrograde protein transport, ER to cytosol [PMID 15215856]; transport; unfolded protein response [PMID 15215856]
RefSeq accession NP_009057
SwissProt accession P55072
GO Pathway:
GO:0007242     intracellular signaling cascade
Sequence:(RefSeq accession:NP_009057; substrate region highlighted if known)
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MASGADSKGD DLSTAILKQK NRPNRLIVDE AINEDNSVVS LSQPKMDELQ LFRGDTVLLK
GKKRREAVCI VLSDDTCSDE KIRMNRVVRN NLRVRLGDVI SIQPCPDVKY GKRIHVLPID
DTVEGITGNL FEVYLKPYFL EAYRPIRKGD IFLVRGGMRA VEFKVVETDP SPYCIVAPDT
VIHCEGEPIK REDEEESLNE VGYDDIGGCR KQLAQIKEMV ELPLRHPALF KAIGVKPPRG
ILLYGPPGTG KTLIARAVAN ETGAFFFLIN GPEIMSKLAG ESESNLRKAF EEAEKNAPAI
IFIDELDAIA PKREKTHGEV ERRIVSQLLT LMDGLKQRAH VIVMAATNRP NSIDPALRRF
GRFDREVDIG IPDATGRLEI LQIHTKNMKL ADDVDLEQVA NETHGHVGAD LAALCSEAAL
QAIRKKMDLI DLEDETIDAE VMNSLAVTMD DFRWALSQSN PSALRETVVE VPQVTWEDIG
GLEDVKRELQ ELVQYPVEHP DKFLKFGMTP SKGVLFYGPP GCGKTLLAKA IANECQANFI
SIKGPELLTM WFGESEANVR EIFDKARQAA PCVLFFDELD SIAKARGGNI GDGGGAADRV
INQILTEMDG MSTKKNVFII GATNRPDIID PAILRPGRLD QLIYIPLPDE KSRVAILKAN
LRKSPVAKDV DLEFLAKMTN GFSGADLTEI CQRACKLAIR ESIESEIRRE RERQTNPSAM
EVEEDDPVPE IRRDHFEEAM RFARRSVSDN DIRKYEMFAQ TLQQSRGFGS FRFPSGNQGG
AGPSQGSGGG TGGSVYTEDN DDDLYG
Records:
Category Evidence Reference
A Mutagenesis Marti F, King PD., The p95-100 kDa ligand of the T cell-specific adaptor (TSAd) protein Src-homology-2 (SH2) domain implicated in TSAd nuclear import is p97 Valosin-containing protein (VCP), [15752563]
End of Record Details