ul_6281----
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PPBD protein
Gene name SH3BP2( Description: SH3-domain binding protein 2. )
Synonyms 3BP2; CRBM; CRPM; FLJ42079; RES4-23
GO annotations GO_component:
GO_function:SH3/SH2 adaptor activity [PMID 9299232]
GO_process: intracellular signaling cascade
RefSeq accession NP_003014
SwissProt accession P78314
Substrate protein
Gene name Itk( Description: IL2-inducible T-cell kinase. )
Synonyms Emt; Tcsk; Tsk
GO annotations GO_component:
GO_function:ATP binding; kinase activity; metal ion binding; nucleotide binding; protein kinase activity; protein-tyrosine kinase activity; transferase activity; zinc ion binding
GO_process: intracellular signaling cascade; protein amino acid phosphorylation
RefSeq accession NP_034713
SwissProt accession
Sequence:(RefSeq accession:NP_034713; substrate region highlighted if known)
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MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKKRT LKGSIELSRI
KCVEIVKSDI SIPCHYKYPF QVVHDNYLLY VFAPDCESRQ RWVLTLKEET RNNNSLVSKY
HPNFWMDGRW RCCSQLEKPA VGCAPYDPSK NASKKPLPPT PEDNRRSFQE PEETLVIALY
DYQTNDPQEL ALRCDEEYYL LDSSEIHWWR VQDKNGHEGY APSSYLVEKS PNNLETYEWY
NKSISRDKAE KLLLDTGKEG AFMVRDSRTP GTYTVSVFTK AIISENPCIK HYHIKETNDS
PKRYYVAEKY VFDSIPLLIQ YHQYNGGGLV TRLRYPVCSW RQKAPVTAGL RYGKWVIQPS
ELTFVQEIGS GQFGLVHLGY WLNKDKVAIK TIQEGAMSEE DFIEEAEVMM KLSHPKLVQL
YGVCLEQAPI CLVFEFMEHG CLSDYLRSQR GLFAAETLLG MCLDVCEGMA YLEKACVIHR
DLAARNCLVG ENQVIKVSDF GMTRFVLDDQ YTSSTGTKFP VKWASPEVFS FSRYSSKSDV
WSFGVLMWEV FSEGKIPYEN RSNSEVVEDI STGFRLYKPR LASCHVYQIM NHCWKEKPED
RPPFSQLLSQ LAEIAEAGL
Records:
Category Evidence Reference
A Inference Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T, et al., Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav, [7511210]
End of Record Details