ul_6302----
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PPBD protein
Gene name SHB( Description: Src homology 2 domain containing adaptor protein B. )
Synonyms RP11-3J10.8; bA3J10.2
GO annotations GO_component: membrane
GO_function:SH3/SH2 adaptor activity [PMID 8302579]
GO_process: angiogenesis; apoptosis; cell differentiation; intracellular signaling cascade
RefSeq accession NP_003019
SwissProt accession Q15464
Substrate protein
Gene name PDGFRA( Description: platelet-derived growth factor receptor, alpha polypeptide. )
Synonyms CD140A; CD140a antigen; EC 2.7.10.1; MGC74795; PDGF-R-alpha; PDGFR2; Rhe-PDGFRA
GO annotations GO_component: integral to plasma membrane [PMID 8586421]; membrane
GO_function:ATP binding; nucleotide binding; platelet-derived growth factor alpha-receptor activity [PMID 10806482]; receptor activity; transferase activity; vascular endothelial growth factor receptor activity
GO_process: cell proliferation [PMID 10806482]; cell surface receptor linked signal transduction [PMID 10806482]; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
RefSeq accession NP_006197
SwissProt accession P16234
GO Pathway:
GO:0007242     intracellular signaling cascade
Sequence:(RefSeq accession:NP_006197; substrate region highlighted if known)
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MGTSHPAFLV LGCLLTGLSL ILCQLSLPSI LPNENEKVVQ LNSSFSLRCF GESEVSWQYP
MSEEESSDVE IRNEENNSGL FVTVLEVSSA SAAHTGLYTC YYNHTQTEEN ELEGRHIYIY
VPDPDVAFVP LGMTDYLVIV EDDDSAIIPC RTTDPETPVT LHNSEGVVPA SYDSRQGFNG
TFTVGPYICE ATVKGKKFQT IPFNVYALKA TSELDLEMEA LKTVYKSGET IVVTCAVFNN
EVVDLQWTYP GEVKGKGITM LEEIKVPSIK LVYTLTVPEA TVKDSGDYEC AARQATREVK
EMKKVTISVH EKGFIEIKPT FSQLEAVNLH EVKHFVVEVR AYPPPRISWL KNNLTLIENL
TEITTDVEKI QEIRYRSKLK LIRAKEEDSG HYTIVAQNED AVKSYTFELL TQVPSSILDL
VDDHHGSTGG QTVRCTAEGT PLPDIEWMIC KDIKKCNNET SWTILANNVS NIITEIHSRD
RSTVEGRVTF AKVEETIAVR CLAKNLLGAE NRELKLVAPT LRSELTVAAA VLVLLVIVII
SLIVLVVIWK QKPRYEIRWR VIESISPDGH EYIYVDPMQL PYDSRWEFPR DGLVLGRVLG
SGAFGKVVEG TAYGLSRSQP VMKVAVKMLK PTARSSEKQA LMSELKIMTH LGPHLNIVNL
LGACTKSGPI YIITEYCFYG DLVNYLHKNR DSFLSHHPEK PKKELDIFGL NPADESTRSY
VILSFENNGD YMDMKQADTT QYVPMLERKE VSKYSDIQRS LYDRPASYKK KSMLDSEVKN
LLSDDNSEGL TLLDLLSFTY QVARGMEFLA SKNCVHRDLA ARNVLLAQGK IVKICDFGLA
RDIMHDSNYV SKGSTFLPVK WMAPESIFDN LYTTLSDVWS YGILLWEIFS LGGTPYPGMM
VDSTFYNKIK SGYRMAKPDH ATSEVYEIMV KCWNSEPEKR PSFYHLSEIV ENLLPGQYKK
SYEKIHLDFL KSDHPAVARM RVDSDNAYIG VTYKNEEDKL KDWEGGLDEQ RLSADSGYII
PLPDIDPVPE EEDLGKRNRH SSQTSEESAI ETGSSSSTFI KREDETIEDI DMMDDIGIDS
SDLVEDSFL
Records:
Category Evidence Reference
A Peptide library Hooshmand-Rad R, Lu L, Heldin CH, Claesson-Welsh L, Welsh M., Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization, [10837138]
End of Record Details