ul_6342----
Record details: Hide
PPBD protein
Gene name SHC1( Description: SHC (Src homology 2 domain containing) transforming protein 1. )
Synonyms FLJ26504; SH2 domain protein C1; SHC; SHCA; Src homology 2 domain-containing-transforming protein C1; p52SHC; p66; p66SHC
GO annotations GO_component: plasma membrane [PMID 14676841]
GO_function:insulin receptor binding [PMID 7537849] [PMID 7559478]; insulin-like growth factor receptor binding [PMID 7541045]; phospholipid binding [PMID 14676841]; protein binding [PMID 8491186]; transmembrane receptor protein tyrosine kinase adaptor protein activity [PMID 14676841]
GO_process: activation of MAPK activity [PMID 14676841]; intracellular signaling cascade; positive regulation of cell proliferation [PMID 14676841]; positive regulation of mitosis [PMID 14676841]; regulation of cell growth; regulation of epidermal growth factor receptor activity [PMID 1623525]
RefSeq accession NP_892113
SwissProt accession P29353
Substrate protein
Gene name Fcer1g( Description: Fc receptor, IgE, high affinity I, gamma polypeptide. )
Synonyms AI573376; CD23; FcR-gamma; FcR[g]; FcRgamma; Fce1g; Ly-50
GO annotations GO_component: external side of plasma membrane; integral to membrane; integral to plasma membrane; lipid raft; membrane; plasma membrane
GO_function:IgE binding; IgG binding; protein binding; receptor activity; transmembrane receptor activity
GO_process: antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class II; cell surface receptor linked signal transduction; defense response to bacterium; immunoglobulin mediated immune response; neutrophil chemotaxis; phagocytosis, engulfment; positive regulation of immune response; positive regulation of interleukin-10 biosynthesis; positive regulation of phagocytosis; positive regulation of tumor necrosis factor-alpha biosynthesis; positive regulation of type IIa hypersensitivity; positive regulation of type III hypersensitivity; regulation of immune response; signal transduction
RefSeq accession NP_034315
SwissProt accession
Sequence:(RefSeq accession:NP_034315; substrate region highlighted if known)
1
61
MISAVILFLL LLVEQAAALG EPQLCYILDA VLFLYGIVLT LLYCRLKIQV RKAAIASREK
ADAVYTGLNT RSQETYETLK HEKPPQ
Records:
Category Evidence Reference
A Inference Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T, et al., Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav, [7511210]
End of Record Details