ul_6458----
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PPBD protein
Gene name SHC1( Description: SHC (Src homology 2 domain containing) transforming protein 1. )
Synonyms FLJ26504; SH2 domain protein C1; SHC; SHCA; Src homology 2 domain-containing-transforming protein C1; p52SHC; p66; p66SHC
GO annotations GO_component: plasma membrane [PMID 14676841]
GO_function:insulin receptor binding [PMID 7537849] [PMID 7559478]; insulin-like growth factor receptor binding [PMID 7541045]; phospholipid binding [PMID 14676841]; protein binding [PMID 8491186]; transmembrane receptor protein tyrosine kinase adaptor protein activity [PMID 14676841]
GO_process: activation of MAPK activity [PMID 14676841]; intracellular signaling cascade; positive regulation of cell proliferation [PMID 14676841]; positive regulation of mitosis [PMID 14676841]; regulation of cell growth; regulation of epidermal growth factor receptor activity [PMID 1623525]
RefSeq accession NP_892113
SwissProt accession P29353
Substrate protein
Gene name CALD1( Description: caldesmon 1. )
Synonyms
GO annotations GO_component:
GO_function:
GO_process:
RefSeq accession NP_989489
SwissProt accession
Sequence:(RefSeq accession:NP_989489; substrate region highlighted if known)
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MDDFERRREL RRQKREEMRL EAERLSYQRN DDDEEEAARE RRRRARQERL RQKEEGDVSG
EVTEKSEVNA QNSVAEEETK RSTDDEAALL ERLARREERR QKRLQEALER QKEFDPTITD
GSLSVPSRRE VNNVEENEIT GKEEKVETRQ GRCEIEETET VTKSYQRNNW RQDGEEEGKK
EEKDSEEEKP KEVPTEENQV DVAVEKSTDK EEVVETKTLA VNAENDTNAM LEGEQSITDA
ADKEKEEAEK EREKLEAEEK ERLKAEEEKK AAEEKQKAEE EKKAAEERER AKAEEEKRAA
EERERAKAEE ERKAAEERAK AEEERKAAEE RAKAEEERKA AEERAKAEKE RKAAEERERA
KAEEEKRAAE EKARLEAEKL KEKKKMEEKK AQEEKAQANL LRKQEEDKEA KVEAKKESLP
EKLQPTSKKD QVKDNKDKEK APKEEMKSVW DRKRGVPEQK AQNGERELTT PKLKSTENAF
GRSNLKGAAN AEAGSEKLKE KQQEAAVELD ELKKRREERR KILEEEEQKK KQEEAERKIR
EEEEKKRMKE EIERRRAEAA EKRQKVPEDG VSEEKKPFKC FSPKGSSLKI EERAEFLNKS
AQKSGMKPAH TTAVVSKIDS RLEQYTSAVV GNKAAKPAKP AASDLPVPAE GVRNIKSMWE
KGNVFSSPGG TGTPNKETAG LKVGVSSRIN EWLTKTPEGN KSPAPKPSDL RPGDVSGKRN
LWEKQSVEKP AASSSKVTAT GKKSETNGLR QFEKEP
Records:
Category Evidence Reference
A Mutagenesis Wang Z, Danielsen AJ, Maihle NJ, McManus MJ., Tyrosine phosphorylation of caldesmon is required for binding to the Shc.Grb2 complex, [10559276]
End of Record Details