ul_6494----
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PPBD protein
Gene name SHC1
Synonyms SH2 domain protein C1; Src homology 2 domain-containing-transforming protein C1
GO annotations GO_component: plasma membrane [PMID 14676841]
GO_function:insulin receptor binding [PMID 7537849] [PMID 7559478]; insulin-like growth factor receptor binding [PMID 7541045]; phospholipid binding [PMID 14676841]; protein binding [PMID 8491186]; transmembrane receptor protein tyrosine kinase adaptor protein activity [PMID 14676841]
GO_process: activation of MAPK activity [PMID 14676841]; intracellular signaling cascade; positive regulation of cell proliferation [PMID 14676841]; positive regulation of mitosis [PMID 14676841]; regulation of cell growth; regulation of epidermal growth factor receptor activity [PMID 1623525]
RefSeq accession NP_003020
SwissProt accession P29353
Substrate protein
Gene name ESR1( Description: estrogen receptor 1. )
Synonyms DKFZp686N23123; ER; ER-alpha; ESR; ESRA; Era; Estradiol receptor; NR3A1
GO annotations GO_component: chromatin remodeling complex [PMID 12351687]; membrane [PMID 11960618]; nucleus
GO_function:estrogen receptor activity [PMID 3753802]; lipid binding; metal ion binding; nitric-oxide synthase regulator activity [PMID 12389206]; protein binding [PMID 7641693] [PMID 10359819]; sequence-specific DNA binding; steroid binding; steroid hormone receptor activity [PMID 11004670]; transcription factor activity; zinc ion binding
GO_process: cell growth [PMID 9171231]; estrogen receptor signaling pathway [PMID 3753802]; negative regulation of mitosis [PMID 12119130]; regulation of transcription, DNA-dependent [PMID 3753802]; signal transduction [PMID 10749889] [PMID 10970861]
RefSeq accession NP_000116
SwissProt accession P03372
GO Pathway:
GO:0007165     signal transduction
Sequence:(RefSeq accession:NP_000116; substrate region highlighted if known)
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MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA VYNYPEGAAY
EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL NSVSPSPLML LHPPPQLSPF
LQPHGQQVPY YLENEPSGYT VREAGPPAFY RPNSDNRRQG GRERLASTND KGSMAMESAK
ETRYCAVCND YASGYHYGVW SCEGCKAFFK RSIQGHNDYM CPATNQCTID KNRRKSCQAC
RLRKCYEVGM MKGGIRKDRR GGRMLKHKRQ RDDGEGRGEV GSAGDMRAAN LWPSPLMIKR
SKKNSLALSL TADQMVSALL DAEPPILYSE YDPTRPFSEA SMMGLLTNLA DRELVHMINW
AKRVPGFVDL TLHDQVHLLE CAWLEILMIG LVWRSMEHPG KLLFAPNLLL DRNQGKCVEG
MVEIFDMLLA TSSRFRMMNL QGEEFVCLKS IILLNSGVYT FLSSTLKSLE EKDHIHRVLD
KITDTLIHLM AKAGLTLQQQ HQRLAQLLLI LSHIRHMSNK GMEHLYSMKC KNVVPLYDLL
LEMLDAHRLH APTSRGGASV EETDQSHLAT AGSTSSHSLQ KYYITGEAEG FPATV
Records:
Category Evidence Reference
A Inference Song RX, McPherson RA, Adam L, Bao Y, Shupnik M, Kumar R, Santen RJ., Linkage of rapid estrogen action to MAPK activation by ERalpha-Shc association and Shc pathway activation, [11773443]
End of Record Details