ul_6513----
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PPBD protein
Gene name SHC1
Synonyms SH2 domain protein C1; Src homology 2 domain-containing-transforming protein C1
GO annotations GO_component: plasma membrane [PMID 14676841]
GO_function:insulin receptor binding [PMID 7537849] [PMID 7559478]; insulin-like growth factor receptor binding [PMID 7541045]; phospholipid binding [PMID 14676841]; protein binding [PMID 8491186]; transmembrane receptor protein tyrosine kinase adaptor protein activity [PMID 14676841]
GO_process: activation of MAPK activity [PMID 14676841]; intracellular signaling cascade; positive regulation of cell proliferation [PMID 14676841]; positive regulation of mitosis [PMID 14676841]; regulation of cell growth; regulation of epidermal growth factor receptor activity [PMID 1623525]
RefSeq accession NP_003020
SwissProt accession P29353
Substrate protein
Gene name Prkcd( Description: protein kinase C, delta. )
Synonyms Pkcd
GO annotations GO_component: cytoplasm; membrane
GO_function:diacylglycerol binding; diacylglycerol-activated phospholipid-dependent protein kinase C activity; metal ion binding; nucleotide binding; protein binding; protein kinase C activity; transferase activity; zinc ion binding
GO_process: B cell proliferation; immunoglobulin mediated immune response; induction of apoptosis; intracellular signaling cascade; protein amino acid phosphorylation
RefSeq accession NP_579841
SwissProt accession
Sequence:(RefSeq accession:NP_579841; substrate region highlighted if known)
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MAPFLRISFN SYELGSLQAE DDASQPFCAV KMKEALTTDR GKTLVQKKPT MYPEWKSTFD
AHIYEGRVIQ IVLMRAAEDP MSEVTVGVSV LAERCKKNNG KAEFWLDLQP QAKVLMCVQY
FLEDGDCKQS MRSEEEAMFP TMNRRGAIKQ AKIHYIKNHE FIATFFGQPT FCSVCKEFVW
GLNKQGYKCR QCNAAIHKKC IDKIIGRCTG TATNSRDTIF QKERFNIDMP HRFKVYNYMS
PTFCDHCGTL LWGLVKQGLK CEDCGMNVHH KCREKVANLC GINQKLLAEA LNQVTQKASR
KPETPETVGI YQGFEKKTAV SGNDIPDNNG TYGKIWEGSN RCRLENFTFQ KVLGKGSFGK
VLLAELKGKE RYFAIKYLKK DVVLIDDDVE CTMVEKRVLA LAWENPFLTH LICTFQTKDH
LFFVMEFLNG GDLMFHIQDK GRFELYRATF YAAEIICGLQ FLHGKGIIYR DLKLDNVMLD
KDGHIKIADF GMCKENIFGE NRASTFCGTP DYIAPEILQG LKYSFSVDWW SFGVLLYEML
IGQSPFHGDD EDELFESIRV DTPHYPRWIT KESKDIMEKL FERDPAKRLG VTGNIRLHPF
FKTINWNLLE KRKVEPPFKP KVKSPSDYSN FDPEFLNEKP QLSFSDKNLI DSMDQTAFKG
FSFVNPKYEQ FLE
Records:
Category Evidence Reference
A Mutagenesis Leitges M, Gimborn K, Elis W, Kalesnikoff J, Hughes MR, Krystal G, Huber M., Protein kinase C-delta is a negative regulator of antigen-induced mast cell degranulation, [12024011]
End of Record Details