ul_652----
Record details: Hide
PPBD protein
Gene name YWHAQ( Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide. )
Synonyms 14-3-3; 14-3-3 protein T-cell; 14-3-3 protein tau; 1C5; HS1; HS1 protein
GO annotations GO_component:
GO_function:protein domain specific binding; protein kinase C inhibitor activity
GO_process: exocytosis; regulation of progression through cell cycle
RefSeq accession NP_006817
SwissProt accession P27348
Substrate protein
Gene name CBL( Description: Cas-Br-M (murine) ecotropic retroviral transforming sequence. )
Synonyms C-CBL; CBL2; Casitas B-lineage lymphoma proto-oncogene; EC 6.3.2.-; Proto-oncogene c-CBL; RING finger protein 55; RNF55; Signal transduction protein CBL
GO annotations GO_component: nucleus; plasma membrane [PMID 15465819]
GO_function:calcium ion binding; ligase activity; protein binding [PMID 11891219]; signal transducer activity; transcription factor activity [PMID 2030914]; ubiquitin-protein ligase activity [PMID 15465819]; zinc ion binding
GO_process: cell surface receptor linked signal transduction [PMID 15465819]; epidermal growth factor receptor signaling pathway [PMID 15465819]; intracellular signaling cascade; positive regulation of receptor mediated endocytosis [PMID 15465819]; protein ubiquitination [PMID 15465819]
RefSeq accession NP_005179
SwissProt accession P22681
Sequence:(RefSeq accession:NP_005179; substrate region highlighted if known)
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
MAGNVKKSSG AGGGSGSGGS GSGGLIGLMK DAFQPHHHHH HHLSPHPPGT VDKKMVEKCW
KLMDKVVRLC QNPKLALKNS PPYILDLLPD TYQHLRTILS RYEGKMETLG ENEYFRVFME
NLMKKTKQTI SLFKEGKERM YEENSQPRRN LTKLSLIFSH MLAELKGIFP SGLFQGDTFR
ITKADAAEFW RKAFGEKTIV PWKSFRQALH EVHPISSGLE AMALKSTIDL TCNDYISVFE
FDIFTRLFQP WSSLLRNWNS LAVTHPGYMA FLTYDEVKAR LQKFIHKPGS YIFRLSCTRL
GQWAIGYVTA DGNILQTIPH NKPLFQALID GFREGFYLFP DGRNQNPDLT GLCEPTPQDH
IKVTQEQYEL YCEMGSTFQL CKICAENDKD VKIEPCGHLM CTSCLTSWQE SEGQGCPFCR
CEIKGTEPIV VDPFDPRGSG SLLRQGAEGA PSPNYDDDDD ERADDTLFMM KELAGAKVER
PPSPFSMAPQ ASLPPVPPRL DLLPQRVCVP SSASALGTAS KAASGSLHKD KPLPVPPTLR
DLPPPPPPDR PYSVGAESRP QRRPLPCTPG DCPSRDKLPP VPSSRLGDSW LPRPIPKVPV
SAPSSSDPWT GRELTNRHSL PFSLPSQMEP RPDVPRLGST FSLDTSMSMN SSPLVGPECD
HPKIKPSSSA NAIYSLAARP LPVPKLPPGE QCEGEEDTEY MTPSSRPLRP LDTSQSSRAC
DCDQQIDSCT YEAMYNIQSQ APSITESSTF GEGNLAAAHA NTGPEESENE DDGYDVPKPP
VPAVLARRTL SDISNASSSF GWLSLDGDPT TNVTEGSQVP ERPPKPFPRR INSERKAGSC
QQGSGPAASA ATASPQLSSE IENLMSQGYS YQDIQKALVI AQNNIEMAKN ILREFVSISS
PAHVAT
Records:
Category Evidence Reference
A Mutagenesis Liu YC, Liu Y, Elly C, Yoshida H, Lipkowitz S, Altman A., Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif., [9092538]
End of Record Details