ul_6547----
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PPBD protein
Gene name SLA( Description: Src-like-adaptor. )
Synonyms SLA1; SLAP; Src-like-adapter protein 1; hSLAP
GO annotations GO_component:
GO_function:SH3/SH2 adaptor activity [PMID 7543898]
GO_process: intracellular signaling cascade
RefSeq accession NP_006739
SwissProt accession Q13239
Substrate protein
Gene name PDGFRB( Description: platelet-derived growth factor receptor, beta polypeptide. )
Synonyms CD140B; CD140b antigen; EC 2.7.10.1; JTK12; PDGF-R-beta; PDGFR; PDGFR1
GO annotations GO_component: integral to membrane; membrane
GO_function:ATP binding; nucleotide binding; platelet activating factor receptor activity [PMID 2536956]; platelet-derived growth factor receptor activity [PMID 2536956]; protein binding [PMID 2157284]; receptor activity; transferase activity; vascular endothelial growth factor receptor activity
GO_process: protein amino acid phosphorylation; signal transduction [PMID 2536956] [PMID 10821867]; transmembrane receptor protein tyrosine kinase signaling pathway
RefSeq accession NP_002600
SwissProt accession P09619
GO Pathway:
GO:0007242     intracellular signaling cascade
Sequence:(RefSeq accession:NP_002600; substrate region highlighted if known)
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MRLPGAMPAL ALKGELLLLS LLLLLEPQIS QGLVVTPPGP ELVLNVSSTF VLTCSGSAPV
VWERMSQEPP QEMAKAQDGT FSSVLTLTNL TGLDTGEYFC THNDSRGLET DERKRLYIFV
PDPTVGFLPN DAEELFIFLT EITEITIPCR VTDPQLVVTL HEKKGDVALP VPYDHQRGFS
GIFEDRSYIC KTTIGDREVD SDAYYVYRLQ VSSINVSVNA VQTVVRQGEN ITLMCIVIGN
EVVNFEWTYP RKESGRLVEP VTDFLLDMPY HIRSILHIPS AELEDSGTYT CNVTESVNDH
QDEKAINITV VESGYVRLLG EVGTLQFAEL HRSRTLQVVF EAYPPPTVLW FKDNRTLGDS
SAGEIALSTR NVSETRYVSE LTLVRVKVAE AGHYTMRAFH EDAEVQLSFQ LQINVPVRVL
ELSESHPDSG EQTVRCRGRG MPQPNIIWSA CRDLKRCPRE LPPTLLGNSS EEESQLETNV
TYWEEEQEFE VVSTLRLQHV DRPLSVRCTL RNAVGQDTQE VIVVPHSLPF KVVVISAILA
LVVLTIISLI ILIMLWQKKP RYEIRWKVIE SVSSDGHEYI YVDPMQLPYD STWELPRDQL
VLGRTLGSGA FGQVVEATAH GLSHSQATMK VAVKMLKSTA RSSEKQALMS ELKIMSHLGP
HLNVVNLLGA CTKGGPIYII TEYCRYGDLV DYLHRNKHTF LQHHSDKRRP PSAELYSNAL
PVGLPLPSHV SLTGESDGGY MDMSKDESVD YVPMLDMKGD VKYADIESSN YMAPYDNYVP
SAPERTCRAT LINESPVLSY MDLVGFSYQV ANGMEFLASK NCVHRDLAAR NVLICEGKLV
KICDFGLARD IMRDSNYISK GSTFLPLKWM APESIFNSLY TTLSDVWSFG ILLWEIFTLG
GTPYPELPMN EQFYNAIKRG YRMAQPAHAS DEIYEIMQKC WEEKFEIRPP FSQLVLLLER
LLGEGYKKKY QQVDEEFLRS DHPAILRSQA RLPGFHGLRS PLDTSSVLYT AVQPNEGDND
YIIPLPDPKP EVADEGPLEG SPSLASSTLN EVNTSSTISC DSPLEPQDEP EPEPQLELQV
EPEPELEQLP DSGCPAPRAE AEDSFL
Records:
Category Evidence Reference
A Mutagenesis Roche S, Alonso G, Kazlauskas A, Dixit VM, Courtneidge SA, Pandey A., Src-like adaptor protein (Slap) is a negative regulator of mitogenesis, [9742401]
End of Record Details