ul_6586----
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PPBD protein
Gene name SOCS1( Description: suppressor of cytokine signaling 1. )
Synonyms CIS1; CISH1; JAB; JAK-binding protein; SOCS-1; SSI-1; SSI1; STAT-induced STAT inhibitor 1; TIP-3; TIP3; Tec-interacting protein 3
GO annotations GO_component: cytoplasm [PMID 9202126]
GO_function:insulin-like growth factor receptor binding [PMID 9727029]; protein kinase binding [PMID 9727029]; protein kinase inhibitor activity [PMID 9202125]
GO_process: cytokine and chemokine mediated signaling pathway; intracellular signaling cascade; JAK-STAT cascade [PMID 9202126]; negative regulation of insulin receptor signaling pathway; negative regulation of JAK-STAT cascade [PMID 9727029]; negative regulation of tyrosine phosphorylation of Stat3 protein; regulation of cell growth; regulation of protein amino acid phosphorylation; ubiquitin cycle
RefSeq accession NP_003736
SwissProt accession O15524
Substrate protein
Gene name JAK2( Description: Janus kinase 2 (a protein tyrosine kinase). )
Synonyms EC 2.7.10.2; JAK-2; Janus kinase 2
GO annotations GO_component: cytoskeleton
GO_function:ATP binding; Janus kinase activity; nucleotide binding; protein-tyrosine kinase activity [PMID 9670957]; receptor binding [PMID 11201744]; SH2 domain binding [PMID 9727029]; transferase activity
GO_process: cell motility [PMID 9670957]; intracellular signaling cascade [PMID 9590174]; JAK-STAT cascade [PMID 9670957]; mesoderm development [PMID 9590174]; protein amino acid phosphorylation [PMID 9670957]; regulation of progression through cell cycle [PMID 10692450]
RefSeq accession NP_004963
SwissProt accession O60674
GO Pathway:
GO:0007259     JAK-STAT cascade
GO:0006928     cell motility
GO:0007242     intracellular signaling cascade
GO:0019221     cytokine and chemokine mediated signaling pathway
Sequence:(RefSeq accession:NP_004963; substrate region highlighted if known)
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1021
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MGMACLTMTE MEGTSTSSIY QNGDISGNAN SMKQIDPVLQ VYLYHSLGKS EADYLTFPSG
EYVAEEICIA ASKACGITPV YHNMFALMSE TERIWYPPNH VFHIDESTRH NVLYRIRFYF
PRWYCSGSNR AYRHGISRGA EAPLLDDFVM SYLFAQWRHD FVHGWIKVPV THETQEECLG
MAVLDMMRIA KENDQTPLAI YNSISYKTFL PKCIRAKIQD YHILTRKRIR YRFRRFIQQF
SQCKATARNL KLKYLINLET LQSAFYTEKF EVKEPGSGPS GEEIFATIII TGNGGIQWSR
GKHKESETLT EQDLQLYCDF PNIIDVSIKQ ANQEGSNESR VVTIHKQDGK NLEIELSSLR
EALSFVSLID GYYRLTADAH HYLCKEVAPP AVLENIQSNC HGPISMDFAI SKLKKAGNQT
GLYVLRCSPK DFNKYFLTFA VERENVIEYK HCLITKNENE EYNLSGTKKN FSSLKDLLNC
YQMETVRSDN IIFQFTKCCP PKPKDKSNLL VFRTNGVSDV PTSPTLQRPT HMNQMVFHKI
RNEDLIFNES LGQGTFTKIF KGVRREVGDY GQLHETEVLL KVLDKAHRNY SESFFEAASM
MSKLSHKHLV LNYGVCVCGD ENILVQEFVK FGSLDTYLKK NKNCINILWK LEVAKQLAWA
MHFLEENTLI HGNVCAKNIL LIREEDRKTG NPPFIKLSDP GISITVLPKD ILQERIPWVP
PECIENPKNL NLATDKWSFG TTLWEICSGG DKPLSALDSQ RKLQFYEDRH QLPAPKWAEL
ANLINNCMDY EPDFRPSFRA IIRDLNSLFT PDYELLTEND MLPNMRIGAL GFSGAFEDRD
PTQFEERHLK FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE
ILKSLQHDNI VKYKGVCYSA GRRNLKLIME YLPYGSLRDY LQKHKERIDH IKLLQYTSQI
CKGMEYLGTK RYIHRDLATR NILVENENRV KIGDFGLTKV LPQDKEYYKV KEPGESPIFW
YAPESLTESK FSVASDVWSF GVVLYELFTY IEKSKSPPAE FMRMIGNDKQ GQMIVFHLIE
LLKNNGRLPR PDGCPDEIYM IMTECWNNNV NQRPSFRDLA LRVDQIRDNM AG
Records:
Category Evidence Reference
A Mutagenesis Yasukawa H, Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T, Ohtsuka S, Imaizumi T, Matsuda T, Ihle JN, Yoshimura A., The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop, [10064597]
A Peptide library Sasaki A, Yasukawa H, Suzuki A, Kamizono S, Syoda T, Kinjyo I, Sasaki M, Johnston JA, Yoshimura A., Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain, [10421843]
A Mutagenesis Ungureanu D, Saharinen P, Junttila I, Hilton DJ, Silvennoinen O., Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1, [11971965]
A Structure Giordanetto F, Kroemer RT., A three-dimensional model of Suppressor Of Cytokine Signalling 1 (SOCS-1), [12676980]
End of Record Details