ul_6604----
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PPBD protein
Gene name SOCS2( Description: suppressor of cytokine signaling 2. )
Synonyms CIS-2; CIS2; Cish2; Cytokine-inducible SH2 protein 2; SOCS-2; SSI-2; SSI2; STAT-induced STAT inhibitor 2; STATI2
GO annotations GO_component: cytoplasm [PMID 9727029]
GO_function:growth hormone receptor binding [PMID 12135564]; insulin-like growth factor receptor binding [PMID 9727029]; JAK pathway signal transduction adaptor activity [PMID 9266833]; prolactin receptor binding; protein binding [PMID 11781573]; SH3/SH2 adaptor activity [PMID 9344848]
GO_process: anti-apoptosis [PMID 9266833]; intracellular signaling cascade; JAK-STAT cascade [PMID 9266833]; negative regulation of signal transduction; regulation of cell growth [PMID 9727029]
RefSeq accession NP_003868
SwissProt accession O14508
Substrate protein
Gene name Ghr( Description: growth hormone receptor. )
Synonyms GHR/BP; MGC124963
GO annotations GO_component: cytoplasm; extrinsic to membrane; integral to membrane; integral to plasma membrane; nucleus
GO_function:growth hormone receptor activity; protein binding; receptor activity
GO_process: endocytosis; growth; positive regulation of cell differentiation; skeletal development
RefSeq accession NP_058790
SwissProt accession
GO Pathway:
GO:0009968     negative regulation of signal transduction
Sequence:(RefSeq accession:NP_058790; substrate region highlighted if known)
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MDLWRVFLTL ALAVSSDMFP GSGATPATLG KASPVLQRIN PSLRESSSGK PRFTKCRSPE
LETFSCYWTE GDDHNLKVPG SIQLYYARRI AHEWTPEWKE CPDYVSAGAN SCYFNSSYTS
IWIPYCIKLT TNGDLLDEKC FTVDEIVQPD PPIGLNWTLL NISLPGIRGD IQVSWQPPPS
ADVLKGWIIL EYEIQYKEVN ETKWKTMSPI WSTSVPLYSL RLDKEHEVRV RSRQRSFEKY
SEFSEVLRVT FPQMDTLAAC EEDFRFPWFL IIIFGIFGVA VMLFVVIFSK QQRIKMLILP
PVPVPKIKGI DPDLLKEGKL EEVNTILGIH DNYKPDFYND DSWVEFIELD IDDADEKTEE
SDTDRLLSDD QEKSAGILGA KDDDSGRTSC YDPDILDTDF HTSDMCDGTS EFAQPQKLKA
EADLLCLDQK NLKNSPYDAS LGSLHPSITL TMEDKPQPLL GSETESTHQL PSTPMSSPVS
LANIDFYAQV SDITPAGGVV LSPGQKIKAG LAQGNTQLEV AAPCQENYSM NSAYFCESDA
KKCIAAAPHM EATTCVKPSF NQEDIYITTE SLTTTARMSE TADTAPDAEP VPDYTTVHTV
KSPRGLILNA TALPLPDKKK FLSSCGYVST DQLNKIMQ
Records:
Category Evidence Reference
A Inference Ram PA, Waxman DJ., SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms, [10585430]
End of Record Details