ul_663----
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PPBD protein
Gene name YWHAQ( Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide. )
Synonyms 14-3-3; 14-3-3 protein T-cell; 14-3-3 protein tau; 1C5; HS1; HS1 protein
GO annotations GO_component:
GO_function:protein domain specific binding; protein kinase C inhibitor activity
GO_process: exocytosis; regulation of progression through cell cycle
RefSeq accession NP_006817
SwissProt accession P27348
Substrate protein
Gene name PRKD1
Synonyms EC 2.7.11.13; Protein kinase C mu type; Protein kinase D; nPKC-D1; nPKC-mu
GO annotations GO_component: cytosol [PMID 10856238]; Golgi apparatus; integral to plasma membrane [PMID 8119958]; plasma membrane [PMID 8119958] [PMID 10856238]
GO_function:ATP binding; atypical protein kinase C activity [PMID 8119958]; diacylglycerol binding; metal ion binding; nucleotide binding; protein binding [PMID 12893243]; protein serine/threonine kinase activity; transferase activity; zinc ion binding
GO_process: cell proliferation [PMID 8119958]; intracellular signaling cascade; protein amino acid phosphorylation [PMID 8119958]
RefSeq accession NP_002733
SwissProt accession Q15139
GO Pathway:
GO:0004674     protein serine/threonine kinase activity
Sequence:(RefSeq accession:NP_002733; substrate region highlighted if known)
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541
601
661
721
781
841
901
MSAPPVLRPP SPLLPVAAAA AAAAAALVPG SGPGPAPFLA PVAAPVGGIS FHLQIGLSRE
PVLLLQDSSG DYSLAHVREM ACSIVDQKFP ECGFYGMYDK ILLFRHDPTS ENILQLVKAA
SDIQEGDLIE VVLSRSATFE DFQIRPHALF VHSYRAPAFC DHCGEMLWGL VRQGLKCEGC
GLNYHKRCAF KIPNNCSGVR RRRLSNVSLT GVSTIRTSSA ELSTSAPDEP LLQKSPSESF
IGREKRSNSQ SYIGRPIHLD KILMSKVKVP HTFVIHSYTR PTVCQYCKKL LKGLFRQGLQ
CKDCRFNCHK RCAPKVPNNC LGEVTINGDL LSPGAESDVV MEEGSDDNDS ERNSGLMDDM
EEAMVQDAEM AMAECQNDSG EMQDPDPDHE DANRTISPST SNNIPLMRVV QSVKHTKRKS
STVMKEGWMV HYTSKDTLRK RHYWRLDSKC ITLFQNDTGS RYYKEIPLSE ILSLEPVKTS
ALIPNGANPH CFEITTANVV YYVGENVVNP SSPSPNNSVL TSGVGADVAR MWEIAIQHAL
MPVIPKGSSV GTGTNLHRDI SVSISVSNCQ IQENVDISTV YQIFPDEVLG SGQFGIVYGG
KHRKTGRDVA IKIIDKLRFP TKQESQLRNE VAILQNLHHP GVVNLECMFE TPERVFVVME
KLHGDMLEMI LSSEKGRLPE HITKFLITQI LVALRHLHFK NIVHCDLKPE NVLLASADPF
PQVKLCDFGF ARIIGEKSFR RSVVGTPAYL APEVLRNKGY NRSLDMWSVG VIIYVSLSGT
FPFNEDEDIH DQIQNAAFMY PPNPWKEISH EAIDLINNLL QVKMRKRYSV DKTLSHPWLQ
DYQTWLDLRE LECKIGERYI THESDDLRWE KYAGEQRLQY PTHLINPSAS HSDTPETEET
EMKALGERVS IL
Records:
Category Evidence Reference
A Mutagenesis Hausser A, Storz P, Link G, Stoll H, Liu YC, Altman A, Pfizenmaier K, Johannes FJ., Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins., [10092600]
End of Record Details