ul_6636----
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PPBD protein
Gene name SOCS3( Description: suppressor of cytokine signaling 3. )
Synonyms ATOD4; CIS-3; CIS3; Cish3; Cytokine-inducible SH2 protein 3; MGC71791; SOCS-3; SSI-3; SSI3; STAT-induced STAT inhibitor 3
GO annotations GO_component:
GO_function:protein kinase inhibitor activity [PMID 9266833]
GO_process: anti-apoptosis [PMID 9266833]; intracellular signaling cascade; JAK-STAT cascade [PMID 9266833]; negative regulation of signal transduction; regulation of cell growth
RefSeq accession NP_003946
SwissProt accession O14543
Substrate protein
Gene name IL12RB2( Description: interleukin 12 receptor, beta 2. )
Synonyms IL-12 receptor beta-2; IL-12R-beta2; RP11-102M16.1
GO annotations GO_component: integral to plasma membrane [PMID 8943050]; membrane
GO_function:interleukin receptor activity [PMID 8943050]; receptor activity
GO_process: cell surface receptor linked signal transduction [PMID 8943050]; positive regulation of cell proliferation [PMID 8943050]
RefSeq accession NP_001550
SwissProt accession Q99665
GO Pathway:
GO:0007166     cell surface receptor linked signal transduction
Sequence:(RefSeq accession:NP_001550; substrate region highlighted if known)
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MAHTFRGCSL AFMFIITWLL IKAKIDACKR GDVTVKPSHV ILLGSTVNIT CSLKPRQGCF
HYSRRNKLIL YKFDRRINFH HGHSLNSQVT GLPLGTTLFV CKLACINSDE IQICGAEIFV
GVAPEQPQNL SCIQKGEQGT VACTWERGRD THLYTEYTLQ LSGPKNLTWQ KQCKDIYCDY
LDFGINLTPE SPESNFTAKV TAVNSLGSSS SLPSTFTFLD IVRPLPPWDI RIKFQKASVS
RCTLYWRDEG LVLLNRLRYR PSNSRLWNMV NVTKAKGRHD LLDLKPFTEY EFQISSKLHL
YKGSWSDWSE SLRAQTPEEE PTGMLDVWYM KRHIDYSRQQ ISLFWKNLSV SEARGKILHY
QVTLQELTGG KAMTQNITGH TSWTTVIPRT GNWAVAVSAA NSKGSSLPTR INIMNLCEAG
LLAPRQVSAN SEGMDNILVT WQPPRKDPSA VQEYVVEWRE LHPGGDTQVP LNWLRSRPYN
VSALISENIK SYICYEIRVY ALSGDQGGCS SILGNSKHKA PLSGPHINAI TEEKGSILIS
WNSIPVQEQM GCLLHYRIYW KERDSNSQPQ LCEIPYRVSQ NSHPINSLQP RVTYVLWMTA
LTAAGESSHG NEREFCLQGK ANWMAFVAPS ICIAIIMVGI FSTHYFQQKV FVLLAALRPQ
WCSREIPDPA NSTCAKKYPI AEEKTQLPLD RLLIDWPTPE DPEPLVISEV LHQVTPVFRH
PPCSNWPQRE KGIQGHQASE KDMMHSASSP PPPRALQAES RQLVDLYKVL ESRGSDPKPE
NPACPWTVLP AGDLPTHDGY LPSNIDDLPS HEAPLADSLE ELEPQHISLS VFPSSSLHPL
TFSCGDKLTL DQLKMRCDSL ML
Records:
Category Evidence Reference
A Mutagenesis Yamamoto K, Yamaguchi M, Miyasaka N, Miura O., SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit, [14559241]
End of Record Details