ul_6669----
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PPBD protein
Gene name SRC
Synonyms EC 2.7.10.2; c-Src; p60-Src; pp60c-src
GO annotations GO_component: integral to membrane; membrane
GO_function:ATP binding; nucleotide binding; protein binding [PMID 8681387] [PMID 9763511]; protein-tyrosine kinase activity [PMID 9020193]; SH2 domain binding [PMID 8070403]; SH3/SH2 adaptor activity [PMID 9020193]; transferase activity
GO_process: protein amino acid phosphorylation; protein kinase cascade [PMID 9020193]; signal complex formation [PMID 9924018]
RefSeq accession NP_005408
SwissProt accession P12931
Substrate protein
Gene name PTPN21( Description: protein tyrosine phosphatase, non-receptor type 21. )
Synonyms EC 3.1.3.48; PTPD1; PTPRL10; Protein-tyrosine phosphatase D1
GO annotations GO_component: cytoskeleton [PMID 7519780]
GO_function:binding; hydrolase activity; protein tyrosine phosphatase activity [PMID 7519780]; structural molecule activity
GO_process: protein amino acid dephosphorylation [PMID 7519780]
RefSeq accession NP_008970
SwissProt accession Q16825
GO Pathway:
GO:0004725     protein tyrosine phosphatase activity
Sequence:(RefSeq accession:NP_008970; substrate region highlighted if known)
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MPLPFGLKLK RTRRYTVSSK SCLVARIQLL NNEFVEFTLS VESTGQESLE AVAQRLELRE
VTYFSLWYYN KQNQRRWVDL EKPLKKQLDK YALEPTVYFG VVFYVPSVSQ LQQEITRYQY
YLQLKKDILE GSIPCTLEQA IQLAGLAVQA DFGDFDQYES QDFLQKFALF PVGWLQDEKV
LEEATQKVAL LHQKYRGLTA PDAEMLYMQE VERMDGYGEE SYPAKDSQGS DISIGACLEG
IFVKHKNGRH PVVFRWHDIA NMSHNKSFFA LELANKEETI QFQTEDMETA KYIWRLCVAR
HKFYRLNQCN LQTQTVTVNP IRRRSSSRMS LPKPQPYVMP PPPQLHYNGH YTEPYASSQD
NLFVPNQNGY YCHSQTSLDR AQIDFNGRIR NGSVYSAHST NSLNNPQPYL QPSPMSSNPS
ITGSDVMRPD YLPSHRHSAV IPPSYRPTPD YETVMKQLNR GLVHAERQSH SLRNLNIGSS
YAYSRPAALV YSQPEIREHA QLPSPAAAHC PFSLSYSFHS PSPYPYPAER RPVVGAVSVP
ELTNAQLQAQ DYPSPNIMRT QVYRPPPPYP PPRPANSTPD LSRHLYISSS NPDLITRRVH
HSVQTFQEDS LPVAHSLQEV SEPLTAARHA QLHKRNSIEV AGLSHGLEGL RLKERTLSAS
AAEVAPRAVS VGSQPSVFTE RTQREGPEEA EGLRYGHKKS LSDATMLIHS SEEEEDEDFE
EESGARAPPA RAREPRPGLA QDPPGCPRVL LAGPLHILEP KAHVPDAEKR MMDSSPVRTT
AEAQRPWRDG LLMPSMSESD LTTSGRYRAR RDSLKKRPVS DLLSGKKNIV EGLPPLGGMK
KTRVDAKKIG PLKLAALNGL SLSRVPLPDE GKEVATRATN DERCKILEQR LEQGMVFTEY
ERILKKRLVD GECSTARLPE NAERNRFQDV LPYDDARVEL VPTKENNTGY INASHIKVSV
SGIEWDYIAT QGPLQNTCQD FWQMVWEQGI AIIAMVTAEE EGGREKSFRY WPRLGSRHNT
VTYGRFKITT RFRTDSGCYA TTGLKMKHLL TGQERTVWHL QYTDWPEHGC PEDLKGFLSY
LEEIQSVRRH TNSTSDPQSP NPPLLVHCSA GVGRTGVVIL SEIMIACLEH NEVLDIPRVL
DMLRQQRMML VQTLCQYTFV YRVLIQFLKS SRLI
Records:
Category Evidence Reference
A Inference Moller NP, Moller KB, Lammers R, Kharitonenkov A, Sures I, Ullrich A., Src kinase associates with a member of a distinct subfamily of protein-tyrosine phosphatases containing an ezrin-like domain, [7519780]
End of Record Details