ul_676----
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PPBD protein
Gene name YWHAQ( Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide. )
Synonyms 14-3-3; 14-3-3 protein T-cell; 14-3-3 protein tau; 1C5; HS1; HS1 protein
GO annotations GO_component:
GO_function:protein domain specific binding; protein kinase C inhibitor activity
GO_process: exocytosis; regulation of progression through cell cycle
RefSeq accession NP_006817
SwissProt accession P27348
Substrate protein
Gene name TERT( Description: telomerase reverse transcriptase. )
Synonyms EC 2.7.7.49; EST2; HEST2; TCS1; TP2; TRT; Telomerase catalytic subunit; Telomerase-associated protein 2; hEST2
GO annotations GO_component: chromosome; chromosome, telomeric region [PMID 12135483]; nucleus; telomerase holoenzyme complex [PMID 12135483]
GO_function:DNA binding; protein binding [PMID 12699629]; RNA binding; RNA-directed DNA polymerase activity; telomeric DNA binding [PMID 9288757]; telomeric template RNA reverse transcriptase activity [PMID 14991929]; transferase activity
GO_process: RNA-dependent DNA replication; telomere maintenance [PMID 12135483]
RefSeq accession NP_937986
SwissProt accession O14746
GO Pathway:
GO:0006605     protein targeting
Sequence:(RefSeq accession:NP_937986; substrate region highlighted if known)
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MPRAPRCRAV RSLLRSHYRE VLPLATFVRR LGPQGWRLVQ RGDPAAFRAL VAQCLVCVPW
DARPPPAAPS FRQVSCLKEL VARVLQRLCE RGAKNVLAFG FALLDGARGG PPEAFTTSVR
SYLPNTVTDA LRGSGAWGLL LRRVGDDVLV HLLARCALFV LVAPSCAYQV CGPPLYQLGA
ATQARPPPHA SGPRRRLGCE RAWNHSVREA GVPLGLPAPG ARRRGGSASR SLPLPKRPRR
GAAPEPERTP VGQGSWAHPG RTRGPSDRGF CVVSPARPAE EATSLEGALS GTRHSHPSVG
RQHHAGPPST SRPPRPWDTP CPPVYAETKH FLYSSGDKEQ LRPSFLLSSL RPSLTGARRL
VETIFLGSRP WMPGTPRRLP RLPQRYWQMR PLFLELLGNH AQCPYGVLLK THCPLRAAVT
PAAGVCAREK PQGSVAAPEE EDTDPRRLVQ LLRQHSSPWQ VYGFVRACLR RLVPPGLWGS
RHNERRFLRN TKKFISLGKH AKLSLQELTW KMSVRDCAWL RRSPGVGCVP AAEHRLREEI
LAKFLHWLMS VYVVELLRSF FYVTETTFQK NRLFFYRKSV WSKLQSIGIR QHLKRVQLRE
LSEAEVRQHR EARPALLTSR LRFIPKPDGL RPIVNMDYVV GARTFRREKR AERLTSRVKA
LFSVLNYERA RRPGLLGASV LGLDDIHRAW RTFVLRVRAQ DPPPELYFVK DRLTEVIASI
IKPQNTYCVR RYAVVQKAAH GHVRKAFKSH VSTLTDLQPY MRQFVAHLQE TSPLRDAVVI
EQSSSLNEAS SGLFDVFLRF MCHHAVRIRG KSYVQCQGIP QGSILSTLLC SLCYGDMENK
LFAGIRRDGL LLRLVDDFLL VTPHLTHAKT FLRTLVRGVP EYGCVVNLRK TVVNFPVEDE
ALGGTAFVQM PAHGLFPWCG LLLDTRTLEV QSDYSSYART SIRASLTFNR GFKAGRNMRR
KLFGVLRLKC HSLFLDLQVN SLQTVCTNIY KILLLQAYRF HACVLQLPFH QQVWKNPTFF
LRVISDTASL CYSILKAKNA GMSLGAKGAA GPLPSEAVQW LCHQAFLLKL TRHRVTYVPL
LGSLRTAQTQ LSRKLPGTTL TALEAAANPA LPSDFKTILD
Records:
Category Evidence Reference
A Mutagenesis Seimiya H, Sawada H, Muramatsu Y, Shimizu M, Ohko K, Yamane K, Tsuruo T., Involvement of 14-3-3 proteins in nuclear localization of telomerase., [10835362]
End of Record Details