ul_6792----
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PPBD protein
Gene name SRC
Synonyms EC 2.7.10.2; c-Src; p60-Src; pp60c-src
GO annotations GO_component: integral to membrane; membrane
GO_function:ATP binding; nucleotide binding; protein binding [PMID 8681387] [PMID 9763511]; protein-tyrosine kinase activity [PMID 9020193]; SH2 domain binding [PMID 8070403]; SH3/SH2 adaptor activity [PMID 9020193]; transferase activity
GO_process: protein amino acid phosphorylation; protein kinase cascade [PMID 9020193]; signal complex formation [PMID 9924018]
RefSeq accession NP_005408
SwissProt accession P12931
Substrate protein
Gene name GJA1( Description: gap junction protein, alpha 1, 43kDa. )
Synonyms CX43; Connexin-43; Cx43; DFNB38; GJAL; Gap junction 43 kDa heart protein; ODDD
GO annotations GO_component: connexon complex [PMID 1850831]; integral to plasma membrane [PMID 15709751]; membrane
GO_function:connexon channel activity [PMID 1850831]; ion transporter activity [PMID 1696265]; protein binding; signal transducer activity [PMID 12761501]
GO_process: cell-cell signaling [PMID 7715640]; gap junction assembly [PMID 15709751]; heart development [PMID 7715640]; muscle contraction [PMID 7715640]; positive regulation of I-kappaB kinase/NF-kappaB cascade [PMID 12761501]; sensory perception of sound; transport [PMID 1696265]
RefSeq accession NP_000156
SwissProt accession P17302
GO Pathway:
GO:0016264     gap junction assembly
Sequence:(RefSeq accession:NP_000156; substrate region highlighted if known)
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MGDWSALGKL LDKVQAYSTA GGKVWLSVLF IFRILLLGTA VESAWGDEQS AFRCNTQQPG
CENVCYDKSF PISHVRFWVL QIIFVSVPTL LYLAHVFYVM RKEEKLNKKE EELKVAQTDG
VNVDMHLKQI EIKKFKYGIE EHGKVKMRGG LLRTYIISIL FKSIFEVAFL LIQWYIYGFS
LSAVYTCKRD PCPHQVDCFL SRPTEKTIFI IFMLVVSLVS LALNIIELFY VFFKGVKDRV
KGKSDPYHAT SGALSPAKDC GSQKYAYFNG CSSPTAPLSP MSPPGYKLVT GDRNNSSCRN
YNKQASEQNW ANYSAEQNRM GQAGSTISNS HAQPFDFPDD NQNSKKLAAG HELQPLAIVD
QRPSSRASSR ASSRPRPDDL EI
Records:
Category Evidence Reference
A Peptide library Toyofuku T, Akamatsu Y, Zhang H, Kuzuya T, Tada M, Hori M., c-Src regulates the interaction between connexin-43 and ZO-1 in cardiac myocytes, [11035005]
End of Record Details