ul_6810----
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PPBD protein
Gene name SRC
Synonyms EC 2.7.10.2; c-Src; p60-Src; pp60c-src
GO annotations GO_component: integral to membrane; membrane
GO_function:ATP binding; nucleotide binding; protein binding [PMID 8681387] [PMID 9763511]; protein-tyrosine kinase activity [PMID 9020193]; SH2 domain binding [PMID 8070403]; SH3/SH2 adaptor activity [PMID 9020193]; transferase activity
GO_process: protein amino acid phosphorylation; protein kinase cascade [PMID 9020193]; signal complex formation [PMID 9924018]
RefSeq accession NP_005408
SwissProt accession P12931
Substrate protein
Gene name Kdr( Description: kinase insert domain protein receptor. )
Synonyms 6130401C07; CD309 antigen; EC 2.7.10.1; Fetal liver kinase 1; Flk-1; Flk1; Kinase NYK; Krd-1; Ly73; Protein-tyrosine kinase receptor flk-1; VEGFR-2; VEGFR2
GO annotations GO_component: integral to membrane; membrane
GO_function:ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein-tyrosine kinase activity; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor receptor activity
GO_process: angiogenesis; cell differentiation; cell fate commitment; cell migration; development; endothelial cell differentiation; hemopoiesis; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; vasculogenesis
RefSeq accession NP_034742
SwissProt accession P35918
Sequence:(RefSeq accession:NP_034742; substrate region highlighted if known)
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MESKALLAVA LWFCVETRAA SVGLPGDFLH PPKLSTQKDI LTILANTTLQ ITCRGQRDLD
WLWPNAQRDS EERVLVTECG GGDSIFCKTL TIPRVVGNDT GAYKCSYRDV DIASTVYVYV
RDYRSPFIAS VSDQHGIVYI TENKNKTVVI PCRGSISNLN VSLCARYPEK RFVPDGNRIS
WDSEIGFTLP SYMISYAGMV FCEAKINDET YQSIMYIVVV VGYRIYDVIL SPPHEIELSA
GEKLVLNCTA RTELNVGLDF TWHSPPSKSH HKKIVNRDVK PFPGTVAKMF LSTLTIESVT
KSDQGEYTCV ASSGRMIKRN RTFVRVHTKP FIAFGSGMKS LVEATVGSQV RIPVKYLSYP
APDIKWYRNG RPIESNYTMI VGDELTIMEV TERDAGNYTV ILTNPISMEK QSHMVSLVVN
VPPQIGEKAL ISPMDSYQYG TMQTLTCTVY ANPPLHHIQW YWQLEEACSY RPGQTSPYAC
KEWRHVEDFQ GGNKIEVTKN QYALIEGKNK TVSTLVIQAA NVSALYKCEA INKAGRGERV
ISFHVIRGPE ITVQPAAQPT EQESVSLLCT ADRNTFENLT WYKLGSQATS VHMGESLTPV
CKNLDALWKL NGTMFSNSTN DILIVAFQNA SLQDQGDYVC SAQDKKTKKR HCLVKQLIIL
ERMAPMITGN LENQTTTIGE TIEVTCPASG NPTPHITWFK DNETLVEDSG IVLRDGNRNL
TIRRVRKEDG GLYTCQACNV LGCARAETLF IIEGAQEKTN LEVIILVGTA VIAMFFWLLL
VIVLRTVKRA NEGELKTGYL SIVMDPDELP LDERCERLPY DASKWEFPRD RLKLGKPLGR
GAFGQVIEAD AFGIDKTATC KTVAVKMLKE GATHSEHRAL MSELKILIHI GHHLNVVNLL
GACTKPGGPL MVIVEFCKFG NLSTYLRGKR NEFVPYKSKG ARFRQGKDYV GELSVDLKRR
LDSITSSQSS ASSGFVEEKS LSDVEEEEAS EELYKDFLTL EHLICYSFQV AKGMEFLASR
KCIHRDLAAR NILLSEKNVV KICDFGLARD IYKDPDYVRK GDARLPLKWM APETIFDRVY
TIQSDVWSFG VLLWEIFSLG ASPYPGVKID EEFCRRLKEG TRMRAPDYTT PEMYQTMLDC
WHEDPNQRPS FSELVEHLGN LLQANAQQDG KDYIVLPMSE TLSMEEDSGL SLPTSPVSCM
EEEEVCDPKF HYDNTAGISH YLQNSKRKSR PVSVKTFEDI PLEEPEVKVI PDDSQTDSGM
VLASEELKTL EDRNKLSPSF GGMMPSKSRE SVASEGSNQT SGYQSGYHSD DTDTTVYSSD
EAGLLKMVDA AVHADSGTTL RSPPV
Records:
Category Evidence Reference
A Mutagenesis Meyer RD, Dayanir V, Majnoun F, Rahimi N., The presence of a single tyrosine residue at the carboxyl domain of vascular endothelial growth factor receptor-2/FLK-1 regulates its autophosphorylation and activation of signaling molecules., [12023952]
End of Record Details