ul_6844----
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PPBD protein
Gene name STAT1( Description: signal transducer and activator of transcription 1, 91kDa. )
Synonyms DKFZp686B04100; ISGF-3; STAT91
GO annotations GO_component: cytoplasm [PMID 10820245]; nucleus [PMID 10820245]
GO_function:calcium ion binding; hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity [PMID 8608597]; protein binding [PMID 12867595]; signal transducer activity; transcription factor activity [PMID 10820245] [PMID 10848577]
GO_process: caspase activation [PMID 10692450]; I-kappaB kinase/NF-kappaB cascade [PMID 10848577]; intracellular signaling cascade; regulation of progression through cell cycle [PMID 10692450]; regulation of transcription, DNA-dependent; response to virus; STAT protein nuclear translocation; transcription; transcription from RNA polymerase II promoter [PMID 9630226]; tyrosine phosphorylation of STAT protein [PMID 10692450]
RefSeq accession NP_009330
SwissProt accession P42224
Substrate protein
Gene name STAT2( Description: signal transducer and activator of transcription 2, 113kDa. )
Synonyms ISGF-3; MGC59816; P113; STAT113
GO annotations GO_component: nucleus
GO_function:calcium ion binding; hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity [PMID 9020188]; signal transducer activity; transcription factor activity
GO_process: intracellular signaling cascade; JAK-STAT cascade [PMID 9020188]; regulation of transcription from RNA polymerase II promoter [PMID 9020188]; response to virus; transcription
RefSeq accession NP_005410
SwissProt accession P52630
GO Pathway:
GO:0007259     JAK-STAT cascade
Sequence:(RefSeq accession:NP_005410; substrate region highlighted if known)
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MAQWEMLQNL DSPFQDQLHQ LYSHSLLPVD IRQYLAVWIE DQNWQEAALG SDDSKATMLF
FHFLDQLNYE CGRCSQDPES LLLQHNLRKF CRDIQPFSQD PTQLAEMIFN LLLEEKRILI
QAQRAQLEQG EPVLETPVES QQHEIESRIL DLRAMMEKLV KSISQLKDQQ DVFCFRYKIQ
AKGKTPSLDP HQTKEQKILQ ETLNELDKRR KEVLDASKAL LGRLTTLIEL LLPKLEEWKA
QQQKACIRAP IDHGLEQLET WFTAGAKLLF HLRQLLKELK GLSCLVSYQD DPLTKGVDLR
NAQVTELLQR LLHRAFVVET QPCMPQTPHR PLILKTGSKF TVRTRLLVRL QEGNESLTVE
VSIDRNPPQL QGFRKFNILT SNQKTLTPEK GQSQGLIWDF GYLTLVEQRS GGSGKGSNKG
PLGVTEELHI ISFTVKYTYQ GLKQELKTDT LPVVIISNMN QLSIAWASVL WFNLLSPNLQ
NQQFFSNPPK APWSLLGPAL SWQFSSYVGR GLNSDQLSML RNKLFGQNCR TEDPLLSWAD
FTKRESPPGK LPFWTWLDKI LELVHDHLKD LWNDGRIMGF VSRSQERRLL KKTMSGTFLL
RFSESSEGGI TCSWVEHQDD DKVLIYSVQP YTKEVLQSLP LTEIIRHYQL LTEENIPENP
LRFLYPRIPR DEAFGCYYQE KVNLQERRKY LKHRLIVVSN RQVDELQQPL ELKPEPELES
LELELGLVPE PELSLDLEPL LKAGLDLGPE LESVLESTLE PVIEPTLCMV SQTVPEPDQG
PVSQPVPEPD LPCDLRHLNT EPMEIFRNCV KIEEIMPNGD PLLAGQNTVD EVYVSRPSHF
YTDGPLMPSD F
Records:
Category Evidence Reference
A Peptide library Gupta S, Yan H, Wong LH, Ralph S, Krolewski J, Schindler C., The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals, [8605877]
A Peptide library Usacheva A, Tian X, Sandoval R, Salvi D, Levy D, Colamonici OR., The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex, [12960323]
End of Record Details