ul_6851----
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PPBD protein
Gene name STAT1( Description: signal transducer and activator of transcription 1, 91kDa. )
Synonyms DKFZp686B04100; ISGF-3; STAT91
GO annotations GO_component: cytoplasm [PMID 10820245]; nucleus [PMID 10820245]
GO_function:calcium ion binding; hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity [PMID 8608597]; protein binding [PMID 12867595]; signal transducer activity; transcription factor activity [PMID 10820245] [PMID 10848577]
GO_process: caspase activation [PMID 10692450]; I-kappaB kinase/NF-kappaB cascade [PMID 10848577]; intracellular signaling cascade; regulation of progression through cell cycle [PMID 10692450]; regulation of transcription, DNA-dependent; response to virus; STAT protein nuclear translocation; transcription; transcription from RNA polymerase II promoter [PMID 9630226]; tyrosine phosphorylation of STAT protein [PMID 10692450]
RefSeq accession NP_009330
SwissProt accession P42224
Substrate protein
Gene name IFNAR1( Description: interferon (alpha, beta and omega) receptor 1. )
Synonyms AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC
GO annotations GO_component: integral to plasma membrane [PMID 8181059]; membrane
GO_function:interferon-alpha/beta receptor activity [PMID 7665574]; receptor activity
GO_process: cell surface receptor linked signal transduction [PMID 7665574]; JAK-STAT cascade [PMID 7665574]; response to virus [PMID 2153461]
RefSeq accession NP_000620
SwissProt accession P17181
Sequence:(RefSeq accession:NP_000620; substrate region highlighted if known)
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541
MMVVLLGATT LVLVAVAPWV LSAAAGGKNL KSPQKVEVDI IDDNFILRWN RSDESVGNVT
FSFDYQKTGM DNWIKLSGCQ NITSTKCNFS SLKLNVYEEI KLRIRAEKEN TSSWYEVDSF
TPFRKAQIGP PEVHLEAEDK AIVIHISPGT KDSVMWALDG LSFTYSLVIW KNSSGVEERI
ENIYSRHKIY KLSPETTYCL KVKAALLTSW KIGVYSPVHC IKTTVENELP PPENIEVSVQ
NQNYVLKWDY TYANMTFQVQ WLHAFLKRNP GNHLYKWKQI PDCENVKTTQ CVFPQNVFQK
GIYLLRVQAS DGNNTSFWSE EIKFDTEIQA FLLPPVFNIR SLSDSFHIYI GAPKQSGNTP
VIQDYPLIYE IIFWENTSNA ERKIIEKKTD VTVPNLKPLT VYCVKARAHT MDEKLNKSSV
FSDAVCEKTK PGNTSKIWLI VGICIALFAL PFVIYAAKVF LRCINYVFFP SLKPSSSIDE
YFSEQPLKNL LLSTSEEQIE KCFIIENIST IATVEETNQT DEDHKKYSSQ TSQDSGNYSN
EDESESKTSE ELQQDFV
Records:
Category Evidence Reference
A Peptide library Li X, Leung S, Kerr IM, Stark GR., Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling, [9121453]
End of Record Details