ul_6934----
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PPBD protein
Gene name STAT3
Synonyms
GO annotations GO_component: cytoplasm [PMID 7512451]; nucleus [PMID 7512451]
GO_function:calcium ion binding; hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity [PMID 7512451]; signal transducer activity; transcription factor activity [PMID 7512451] [PMID 8675499]; transcription factor binding [PMID 15664994]
GO_process: acute-phase response; cell motility [PMID 9670957]; cytokine and chemokine mediated signaling pathway [PMID 15664994]; intracellular signaling cascade; JAK-STAT cascade [PMID 15664994]; negative regulation of transcription from RNA polymerase II promoter [PMID 8675499]; nervous system development [PMID 10205054]; regulation of transcription, DNA-dependent
RefSeq accession NP_644805
SwissProt accession P40763
Substrate protein
Gene name ADRA1B( Description: adrenergic, alpha-1B-, receptor. )
Synonyms ADRA1; ALPHA1BAR; Alpha 1B-adrenoceptor; Alpha 1B-adrenoreceptor
GO annotations GO_component: integral to plasma membrane [PMID 1328250]; membrane
GO_function:adrenoceptor activity; alpha1-adrenergic receptor activity [PMID 1328250]; receptor activity; rhodopsin-like receptor activity
GO_process: cell proliferation [PMID 10820200]; cell-cell signaling [PMID 1328250]; development [PMID 10820200]; G-protein coupled receptor protein signaling pathway [PMID 2154750]; G-protein signaling, coupled to cAMP nucleotide second messenger [PMID 10820200]; protein kinase cascade [PMID 10820200]; signal transduction
RefSeq accession NP_000670
SwissProt accession P35368
Sequence:(RefSeq accession:NP_000670; substrate region highlighted if known)
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MNPDLDTGHN TSAPAHWGEL KNANFTGPNQ TSSNSTLPQL DITRAISVGL VLGAFILFAI
VGNILVILSV ACNRHLRTPT NYFIVNLAMA DLLLSFTVLP FSAALEVLGY WVLGRIFCDI
WAAVDVLCCT ASILSLCAIS IDRYIGVRYS LQYPTLVTRR KAILALLSVW VLSTVISIGP
LLGWKEPAPN DDKECGVTEE PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG
VMKEMSNSKE LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV
GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC SSKEFKRAFV
RILGCQCRGR GRRRRRRRRR LGGCAYTYRP WTRGGSLERS QSRKDSLDDS GSCLSGSQRT
LPSASPSPGY LGRGAPPPVE LCAFPEWKAP GALLSLPAPE PPGRRGRHDS GPLFTFKLLT
EPESPGTDGG ASNGGCEAAA DVANGQPGFK SNMPLAPGQF
Records:
Category Evidence Reference
A Inference Sasaguri T, Teruya H, Ishida A, Abumiya T, Ogata J., Linkage between alpha(1) adrenergic receptor and the Jak/STAT signaling pathway in vascular smooth muscle cells, [10652206]
End of Record Details