ul_6994----

Record details:

PPBD protein

Gene name	STAT5A( Description: signal transducer and activator of transcription 5A. )
Synonyms	MGF; STAT5
GO annotations	GO_component: nucleus GO_function:calcium ion binding; signal transducer activity; transcription factor activity [PMID 7719937] [PMID 8631883] GO_process: immune response; intracellular signaling cascade; JAK-STAT cascade [PMID 7719937]; regulation of transcription from RNA polymerase II promoter [PMID 8631883]; transcription
RefSeq accession	NP_003143
SwissProt accession	P42229

Substrate protein

Gene name	EpoR( Description: erythropoietin receptor. )
Synonyms
GO annotations	GO_component: membrane GO_function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; receptor activity; transmembrane receptor activity GO_process:
RefSeq accession	NP_034279
SwissProt accession

GO Pathway:

GO:0007165 signal transduction

Sequence:(RefSeq accession:NP_034279; substrate region highlighted if known)

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MDKLRVPLWP RVGPLCLLLA GAAWAPSPSL PDPKFESKAA LLASRGSEEL LCFTQRLEDL
VCFWEEAASS GMDFNYSFSY QLEGESRKSC SLHQAPTVRG SVRFWCSLPT ADTSSFVPLE
LQVTEASGSP RYHRIIHINE VVLLDAPAGL LARRAEEGSH VVLRWLPPPG APMTTHIRYE
VDVSAGNRAG GTQRVEVLEG RTECVLSNLR GGTRYTFAVR ARMAEPSFSG FWSAWSEPAS
LLTASDLDPL ILTLSLILVL ISLLLTVLAL LSHRRTLQQK IWPGIPSPES EFEGLFTTHK
GNFQLWLLQR DGCLWWSPGS SFPEDPPAHL EVLSEPRWAV TQAGDPGADD EGPLLEPVGS
EHAQDTYLVL DKWLLPRTPC SENLSGPGGS VDPVTMDEAS ETSSCPSDLA SKPRPEGTSP
SSFEYTILDP SSQLLCPRAL PPELPPTPPH LKYLYLVVSD SGISTDYSSG GSQGVHGDSS
DGPYSHPYEN SLVPDSEPLH PGYVACS

Records:

Category	Evidence	Reference
A	Peptide library	Gobert S, Chretien S, Gouilleux F, Muller O, Pallard C, Dusanter-Fourt I, Groner B, Lacombe C, Gisselbrecht S, Mayeux P., Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation, [8665851]

End of Record Details