ul_7----
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PPBD protein
Gene name NPHP1
Synonyms
GO annotations GO_component: membrane [PMID 10665934]
GO_function:protein domain specific binding; structural molecule activity [PMID 12006559]
GO_process: actin cytoskeleton organization and biogenesis [PMID 12006559]; cell-cell adhesion [PMID 12006559]; excretion [PMID 9361039]; signal transduction [PMID 12244321]; visual behavior [PMID 12205563]
RefSeq accession NP_000263
SwissProt accession O15259
Substrate protein
Gene name CDC25C
Synonyms Dual specificity phosphatase Cdc25C; EC 3.1.3.48
GO annotations GO_component: intracellular; nucleus
GO_function:hydrolase activity; protein tyrosine phosphatase activity [PMID 11078813]
GO_process: cell cycle; cell division; cell proliferation [PMID 11139144]; protein amino acid dephosphorylation; regulation of cyclin-dependent protein kinase activity [PMID 11139144]; regulation of mitosis [PMID 1828290]; traversing start control point of mitotic cell cycle [PMID 2195549]
RefSeq accession NP_001781
SwissProt accession P30307
GO Pathway:
GO:0006605     protein targeting
Sequence:(RefSeq accession:NP_001781; substrate region highlighted if known)
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MSTELFSSTR EEGSSGSGPS FRSNQRKMLN LLLERDTSFT VCPDVPRTPV GKFLGDSANL
SILSGGTPKC CLDLSNLSSG EITATQLTTS ADLDETGHLD SSGLQEVHLA GMNHDQHLMK
CSPAQLLCST PNGLDRGHRK RDAMCSSSAN KENDNGNLVD SEMKYLGSPI TTVPKLDKNP
NLGEDQAEEI SDELMEFSLK DQEAKVSRSG LYRSPSMPEN LNRPRLKQVE KFKDNTIPDK
VKKKYFSGQG KLRKGLCLKK TVSLCDITIT QMLEEDSNQG HLIGDFSKVC ALPTVSGKHQ
DLKYVNPETV AALLSGKFQG LIEKFYVIDC RYPYEYLGGH IQGALNLYSQ EELFNFFLKK
PIVPLDTQKR IIIVFHCEFS SERGPRMCRC LREEDRSLNQ YPALYYPELY ILKGGYRDFF
PEYMELCEPQ SYCPMHHQDH KTELLRCRSQ SKVQEGERQL REQIALLVKD MSP
Records:
Category Evidence Reference
A Inference Graves PR, Yu L, Schwarz JK, Gales J, Sausville EA, O'Connor PM, Piwnica-Worms H., The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01., [10681541]
End of Record Details