ul_704----
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PPBD protein
Gene name YWHAQ( Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide. )
Synonyms 14-3-3; 14-3-3 protein T-cell; 14-3-3 protein tau; 1C5; HS1; HS1 protein
GO annotations GO_component:
GO_function:protein domain specific binding; protein kinase C inhibitor activity
GO_process: exocytosis; regulation of progression through cell cycle
RefSeq accession NP_006817
SwissProt accession P27348
Substrate protein
Gene name CDKN1B( Description: cyclin-dependent kinase inhibitor 1B (p27, Kip1). )
Synonyms CDKN4; Cyclin-dependent kinase inhibitor p27; KIP1; MEN1B; MEN4; P27KIP1; p27Kip1
GO annotations GO_component: cytoplasm [PMID 12093740]; nucleus [PMID 12093740]
GO_function:cyclin-dependent protein kinase inhibitor activity [PMID 10918569]; protein binding [PMID 8756624] [PMID 9106657] [PMID 15057270]; transforming growth factor beta receptor, cytoplasmic mediator activity [PMID 8033212]
GO_process: cell cycle; cell cycle arrest [PMID 12093740]; negative regulation of cell proliferation [PMID 8033212]; regulation of cyclin-dependent protein kinase activity [PMID 8033212]
RefSeq accession NP_004055
SwissProt accession P46527
Sequence:(RefSeq accession:NP_004055; substrate region highlighted if known)
1
61
121
181
MSNVRVSNGS PSLERMDARQ AEHPKPSACR NLFGPVDHEE LTRDLEKHCR DMEEASQRKW
NFDFQNHKPL EGKYEWQEVE KGSLPEFYYR PPRPPKGACK VPAQESQDVS GSRPAAPLIG
APANSEDTHL VDPKTDPSDS QTGLAEQCAG IRKRPATDDS STQNKRANRT EENVSDGSPN
AGSVEQTPKK PGLRRRQT
Records:
Category Evidence Reference
A Mutagenesis Fujita N, Sato S, Katayama K, Tsuruo T., Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization., [12042314]
End of Record Details