ul_71----
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PPBD protein
Gene name SFN( Description: stratifin. )
Synonyms Epithelial cell marker protein 1; Stratifin; YWHAS
GO annotations GO_component: cytoplasm [PMID 10767298]; extracellular space [PMID 8515476]
GO_function:protein domain specific binding; protein kinase C inhibitor activity [PMID 8515476]
GO_process: cell proliferation [PMID 10767298]; negative regulation of protein kinase activity [PMID 8515476]; regulation of progression through cell cycle [PMID 10767298]; signal transduction [PMID 8515476]
RefSeq accession NP_006133
SwissProt accession P31947
Substrate protein
Gene name ITGB2( Description: integrin, beta 2 (complement component 3 receptor 3 and 4 subunit). )
Synonyms CD18; CD18 antigen; Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7
GO annotations GO_component: integral to membrane; integrin complex [PMID 12885943]; membrane
GO_function:protein binding [PMID 12885943]; protein kinase binding [PMID 12885943]; receptor activity
GO_process: antimicrobial humoral response (sensu Vertebrata) [PMID 7686755]; apoptosis [PMID 12885943]; cell adhesion [PMID 1694220]; cell-cell signaling [PMID 12885943]; cell-matrix adhesion; development; inflammatory response [PMID 12885943]; integrin-mediated signaling pathway [PMID 12885943]; leukocyte adhesion [PMID 12885943]; neutrophil chemotaxis [PMID 12885943]; regulation of cell shape [PMID 12885943]; regulation of peptidyl-tyrosine phosphorylation [PMID 12885943]
RefSeq accession NP_000202
SwissProt accession P05107
GO Pathway:
GO:0007159     leukocyte adhesion
Sequence:(RefSeq accession:NP_000202; substrate region highlighted if known)
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MLGLRPPLLA LVGLLSLGCV LSQECTKFKV SSCRECIESG PGCTWCQKLN FTGPGDPDSI
RCDTRPQLLM RGCAADDIMD PTSLAETQED HNGGQKQLSP QKVTLYLRPG QAAAFNVTFR
RAKGYPIDLY YLMDLSYSML DDLRNVKKLG GDLLRALNEI TESGRIGFGS FVDKTVLPFV
NTHPDKLRNP CPNKEKECQP PFAFRHVLKL TNNSNQFQTE VGKQLISGNL DAPEGGLDAM
MQVAACPEEI GWRNVTRLLV FATDDGFHFA GDGKLGAILT PNDGRCHLED NLYKRSNEFD
YPSVGQLAHK LAENNIQPIF AVTSRMVKTY EKLTEIIPKS AVGELSEDSS NVVQLIKNAY
NKLSSRVFLD HNALPDTLKV TYDSFCSNGV THRNQPRGDC DGVQINVPIT FQVKVTATEC
IQEQSFVIRA LGFTDIVTVQ VLPQCECRCR DQSRDRSLCH GKGFLECGIC RCDTGYIGKN
CECQTQGRSS QELEGSCRKD NNSIICSGLG DCVCGQCLCH TSDVPGKLIY GQYCECDTIN
CERYNGQVCG GPGRGLCFCG KCRCHPGFEG SACQCERTTE GCLNPRRVEC SGRGRCRCNV
CECHSGYQLP LCQECPGCPS PCGKYISCAE CLKFEKGPFG KNCSAACPGL QLSNNPVKGR
TCKERDSEGC WVAYTLEQQD GMDRYLIYVD ESRECVAGPN IAAIVGGTVA GIVLIGILLL
VIWKALIHLS DLREYRRFEK EKLKSQWNND NPLFKSATTT VMNPKFAES
Records:
Category Evidence Reference
A Inference Fagerholm SC, Hilden TJ, Nurmi SM, Gahmberg CG., Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms., [16301335]
End of Record Details