ul_7202----
Record details: Hide
PPBD protein
Gene name SYK( Description: spleen tyrosine kinase. )
Synonyms EC 2.7.10.2; Spleen tyrosine kinase
GO annotations GO_component: cytoplasm; T cell receptor complex [PMID 8176201]
GO_function:ATP binding; integrin binding [PMID 12885943]; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding [PMID 8627166] [PMID 9280292] [PMID 12885943]; transferase activity
GO_process: cell proliferation [PMID 10963601]; integrin-mediated signaling pathway [PMID 12885943]; intracellular signaling cascade; leukocyte adhesion [PMID 12885943]; neutrophil chemotaxis [PMID 12885943]; organ morphogenesis [PMID 7477352]; protein amino acid phosphorylation [PMID 8163536]; protein complex assembly [PMID 8163536]
RefSeq accession NP_003168
SwissProt accession P43405
Substrate protein
Gene name Nfam1( Description: Nfat activating molecule with ITAM motif 1. )
Synonyms 4921501M20Rik
GO annotations GO_component: cell surface; integral to membrane; lipid raft; membrane
GO_function:molecular_function; transmembrane receptor activity
GO_process: B cell receptor signaling pathway; cell surface receptor linked signal transduction; inflammatory response; intracellular signaling cascade; positive regulation of B cell receptor signaling pathway; positive regulation of cytokine production; positive regulation of transcription factor activity; regulation of B cell differentiation
RefSeq accession NP_083004
SwissProt accession
GO Pathway:
GO:0030183     B cell differentiation
Sequence:(RefSeq accession:NP_083004; substrate region highlighted if known)
1
61
121
181
MPGYQLTRQG DIHPNVQSKK DLSCRIEDFT RLQRDLPVKL FHTDIHGRRR WEKQINCQHR
PGMENHTRDC MVKLSQANTS ATGIYYFIVE GEETYQSDGV VILVRDTVYQ PPAFKVQEAL
MLGFTSLMSV LGVLGTALLL WKKKQISVLG KHTAKTCSGL KSTVGTTKPP AESVYTSLQR
RETEVYACMK EETGSPVFSQ SPATKEKLNR FEDDNEFNLV YENL
Records:
Category Evidence Reference
A Peptide library Ohtsuka M, Arase H, Takeuchi A, Yamasaki S, Shiina R, Suenaga T, Sakurai D, Yokosuka T, Arase N, Iwashima M, Kitamura T, Moriya H, Saito T., NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling, [15143214]
End of Record Details