ul_7204----

Record details:

PPBD protein

Gene name	SYK( Description: spleen tyrosine kinase. )
Synonyms	EC 2.7.10.2; Spleen tyrosine kinase
GO annotations	GO_component: cytoplasm; T cell receptor complex [PMID 8176201] GO_function:ATP binding; integrin binding [PMID 12885943]; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding [PMID 8627166] [PMID 9280292] [PMID 12885943]; transferase activity GO_process: cell proliferation [PMID 10963601]; integrin-mediated signaling pathway [PMID 12885943]; intracellular signaling cascade; leukocyte adhesion [PMID 12885943]; neutrophil chemotaxis [PMID 12885943]; organ morphogenesis [PMID 7477352]; protein amino acid phosphorylation [PMID 8163536]; protein complex assembly [PMID 8163536]
RefSeq accession	NP_003168
SwissProt accession	P43405

Substrate protein

Gene name	NFAM1( Description: NFAT activating protein with ITAM motif 1. )
Synonyms	CNAIP; Calcineurin/NFAT-activating ITAM-containing protein; FLJ40652; NFAT-activating protein with ITAM motif 1; bK126B4.4
GO annotations	GO_component: integral to membrane [PMID 12615919]; membrane GO_function:transmembrane receptor activity [PMID 12615919] GO_process: B cell differentiation [PMID 15143214]; cell surface receptor linked signal transduction; inflammatory response [PMID 12615919]; intracellular signaling cascade [PMID 12615919]; positive regulation of B cell receptor signaling pathway [PMID 15143214]; positive regulation of cytokine production [PMID 12615919]; positive regulation of transcription factor activity [PMID 12615919]
RefSeq accession	NP_666017
SwissProt accession	Q8NET5

GO Pathway:

GO:0030183 B cell differentiation

Sequence:(RefSeq accession:NP_666017; substrate region highlighted if known)

1
61
121
181
241

MENQPVRWRA LPGLPRPPGL PAAPWLLLGV LLLPGTLRLA GGQSVTHTGL PIMASLANTA
ISFSCRITYP YTPQFKVFTV SYFHEDLQGQ RSPKKPTNCH PGLGTENQSH TLDCQVTLVL
PGASATGTYY CSVHWPHSTV RGSGTFILVR DAGYREPPQS PQKLLLFGFT GLLSVLSVVG
TALLLWNKKR MRGPGKDPTR KCPDPRSASS PKQHPSESVY TALQRRETEV YACIENEDGS
SPTAKQSPLS QERPHRFEDD GELNLVYENL

Records:

Category	Evidence	Reference
A	Peptide library	Ohtsuka M, Arase H, Takeuchi A, Yamasaki S, Shiina R, Suenaga T, Sakurai D, Yokosuka T, Arase N, Iwashima M, Kitamura T, Moriya H, Saito T., NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling, [15143214]

End of Record Details