ul_7204----
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PPBD protein
Gene name SYK( Description: spleen tyrosine kinase. )
Synonyms EC 2.7.10.2; Spleen tyrosine kinase
GO annotations GO_component: cytoplasm; T cell receptor complex [PMID 8176201]
GO_function:ATP binding; integrin binding [PMID 12885943]; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding [PMID 8627166] [PMID 9280292] [PMID 12885943]; transferase activity
GO_process: cell proliferation [PMID 10963601]; integrin-mediated signaling pathway [PMID 12885943]; intracellular signaling cascade; leukocyte adhesion [PMID 12885943]; neutrophil chemotaxis [PMID 12885943]; organ morphogenesis [PMID 7477352]; protein amino acid phosphorylation [PMID 8163536]; protein complex assembly [PMID 8163536]
RefSeq accession NP_003168
SwissProt accession P43405
Substrate protein
Gene name NFAM1( Description: NFAT activating protein with ITAM motif 1. )
Synonyms CNAIP; Calcineurin/NFAT-activating ITAM-containing protein; FLJ40652; NFAT-activating protein with ITAM motif 1; bK126B4.4
GO annotations GO_component: integral to membrane [PMID 12615919]; membrane
GO_function:transmembrane receptor activity [PMID 12615919]
GO_process: B cell differentiation [PMID 15143214]; cell surface receptor linked signal transduction; inflammatory response [PMID 12615919]; intracellular signaling cascade [PMID 12615919]; positive regulation of B cell receptor signaling pathway [PMID 15143214]; positive regulation of cytokine production [PMID 12615919]; positive regulation of transcription factor activity [PMID 12615919]
RefSeq accession NP_666017
SwissProt accession Q8NET5
GO Pathway:
GO:0030183     B cell differentiation
Sequence:(RefSeq accession:NP_666017; substrate region highlighted if known)
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MENQPVRWRA LPGLPRPPGL PAAPWLLLGV LLLPGTLRLA GGQSVTHTGL PIMASLANTA
ISFSCRITYP YTPQFKVFTV SYFHEDLQGQ RSPKKPTNCH PGLGTENQSH TLDCQVTLVL
PGASATGTYY CSVHWPHSTV RGSGTFILVR DAGYREPPQS PQKLLLFGFT GLLSVLSVVG
TALLLWNKKR MRGPGKDPTR KCPDPRSASS PKQHPSESVY TALQRRETEV YACIENEDGS
SPTAKQSPLS QERPHRFEDD GELNLVYENL
Records:
Category Evidence Reference
A Peptide library Ohtsuka M, Arase H, Takeuchi A, Yamasaki S, Shiina R, Suenaga T, Sakurai D, Yokosuka T, Arase N, Iwashima M, Kitamura T, Moriya H, Saito T., NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling, [15143214]
End of Record Details