ul_7235----

Record details:

PPBD protein

Gene name	TEC( Description: tec protein tyrosine kinase. )
Synonyms	MGC126760; MGC126762; PSCTK4
GO annotations	GO_component: GO_function:ATP binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity [PMID 7934162]; nucleotide binding; transferase activity; zinc ion binding GO_process: protein amino acid phosphorylation [PMID 7934162]; protein kinase cascade [PMID 7934162]
RefSeq accession	NP_003206
SwissProt accession	P42680

Substrate protein

Gene name	PTPN18( Description: protein tyrosine phosphatase, non-receptor type 18 (brain-derived). )
Synonyms	BDP1; Brain-derived phosphatase; EC 3.1.3.48
GO annotations	GO_component: nucleus GO_function:hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity [PMID 8950995]; protein tyrosine phosphatase activity GO_process: protein amino acid dephosphorylation [PMID 8950995]
RefSeq accession	NP_055184
SwissProt accession	Q99952

GO Pathway:

GO:0007243 protein kinase cascade

Sequence:(RefSeq accession:NP_055184; substrate region highlighted if known)

1
61
121
181
241
301
361
421

MSRSLDSARS FLERLEARGG REGAVLAGEF SDIQACSAAW KADGVCSTVA GSRPENVRKN
RYKDVLPYDQ TRVILSLLQE EGHSDYINGN FIRGVDGSLA YIATQGPLPH TLLDFWRLVW
EFGVKVILMA CREIENGRKR CERYWAQEQE PLQTGLFCIT LIKEKWLNED IMLRTLKVTF
QKESRSVYQL QYMSWPDRGV PSSPDHMLAM VEEARRLQGS GPEPLCVHCS AGCGRTGVLC
TVDYVRQLLL TQMIPPDFSL FDVVLKMRKQ RPAAVQTEEQ YRFLYHTVAQ MFCSTLQNAS
PHYQNIKENC APLYDDALFL RTPQALLAIP RPPGGVLRSI SVPGSPGHAM ADTYAVVQKR
GAPAGAGSGT QTGTGTGTGA RSAEEAPLYS KVTPRAQRPG AHAEDARGTL PGRVPADQSP
AGSGAYEDVA GGAQTGGLGF NLRIGRPKGP RDPPAEWTRV

Records:

Category	Evidence	Reference
A	Mutagenesis	Aoki N, Ueno S, Mano H, Yamasaki S, Shiota M, Miyazaki H, Yamaguchi-Aoki Y, Matsuda T, Ullrich A., Mutual regulation of protein-tyrosine phosphatase 20 and protein-tyrosine kinase Tec activities by tyrosine phosphorylation and dephosphorylation, [14679216]

End of Record Details