ul_7282----
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PPBD protein
Gene name VAV1( Description: vav 1 oncogene. )
Synonyms VAV
GO annotations GO_component: intracellular; nucleus
GO_function:diacylglycerol binding; metal ion binding; protein binding [PMID 10394361]; Rho guanyl-nucleotide exchange factor activity; transcription factor activity [PMID 2477241]; zinc ion binding
GO_process: intracellular signaling cascade; regulation of Rho protein signal transduction
RefSeq accession NP_005419
SwissProt accession P15498
Substrate protein
Gene name RHOA( Description: ras homolog gene family, member A. )
Synonyms ARH12; ARHA; RHO12; RHOH12
GO annotations GO_component: cytoskeleton; intracellular; membrane
GO_function:GTP binding; GTPase activity [PMID 10436159]; magnesium ion binding; nucleotide binding; protein binding [PMID 11335720] [PMID 11889037] [PMID 12006984] [PMID 12879077]; signal transducer activity [PMID 12761501]
GO_process: actin cytoskeleton organization and biogenesis [PMID 10436159]; positive regulation of I-kappaB kinase/NF-kappaB cascade [PMID 12761501]; positive regulation of NF-kappaB import into nucleus [PMID 12761501]; Rho protein signal transduction [PMID 10436159]; small GTPase mediated signal transduction
RefSeq accession NP_001655
SwissProt accession P06749
Sequence:(RefSeq accession:NP_001655; substrate region highlighted if known)
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MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYVADIEVDG KQVELALWDT
AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD
LRNDEHTRRE LAKMKQEPVK PEEGRDMANR IGAFGYMECS AKTKDGVREV FEMATRAALQ
ARRGKKKSGC LVL
Records:
Category Evidence Reference
A Inference Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T, et al., Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav, [7511210]
End of Record Details