ul_7287----
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PPBD protein
Gene name VAV1( Description: vav 1 oncogene. )
Synonyms VAV
GO annotations GO_component: intracellular; nucleus
GO_function:diacylglycerol binding; metal ion binding; protein binding [PMID 10394361]; Rho guanyl-nucleotide exchange factor activity; transcription factor activity [PMID 2477241]; zinc ion binding
GO_process: intracellular signaling cascade; regulation of Rho protein signal transduction
RefSeq accession NP_005419
SwissProt accession P15498
Substrate protein
Gene name RPS6KB1( Description: ribosomal protein S6 kinase, 70kDa, polypeptide 1. )
Synonyms 70 kDa ribosomal protein S6 kinase 1; EC 2.7.11.1; P70S6K; PS6K; Ribosomal protein S6 kinase I; S6K; S6K1; STK14A; p70 S6 kinase alpha; p70(S6K)-alpha; p70-S6K; p70-alpha
GO annotations GO_component:
GO_function:ATP binding; nucleotide binding; protein serine/threonine kinase activity; transferase activity
GO_process: protein amino acid phosphorylation; signal transduction [PMID 1922062]
RefSeq accession NP_003152
SwissProt accession P23443
Sequence:(RefSeq accession:NP_003152; substrate region highlighted if known)
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MRRRRRRDGF YPAPDFRDRE AEDMAGVFDI DLDQPEDAGS EDELEEGGQL NESMDHGGVG
PYELGMEHCE KFEISETSVN RGPEKIRPEC FELLRVLGKG GYGKVFQVRK VTGANTGKIF
AMKVLKKAMI VRNAKDTAHT KAERNILEEV KHPFIVDLIY AFQTGGKLYL ILEYLSGGEL
FMQLEREGIF MEDTACFYLA EISMALGHLH QKGIIYRDLK PENIMLNHQG HVKLTDFGLC
KESIHDGTVT HTFCGTIEYM APEILMRSGH NRAVDWWSLG ALMYDMLTGA PPFTGENRKK
TIDKILKCKL NLPPYLTQEA RDLLKKLLKR NAASRLGAGP GDAGEVQAHP FFRHINWEEL
LARKVEPPFK PLLQSEEDVS QFDSKFTRQT PVDSPDDSTL SESANQVFLG FTYVAPSVLE
SVKEKFSFEP KIRSPRRFIG SPRTPVSPVK FSPGDFWGRG ASASTANPQT PVEYPMETSG
IEQMDVTMSG EASAPLPIRQ PNSGPYKKQA FPMISKRPEH LRMNL
Records:
Category Evidence Reference
A Inference Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T, et al., Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav, [7511210]
End of Record Details