ul_7368----
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PPBD protein
Gene name VAV2( Description: vav 2 oncogene. )
Synonyms
GO annotations GO_component: intracellular
GO_function:diacylglycerol binding; metal ion binding; protein binding [PMID 15618286]; Rho guanyl-nucleotide exchange factor activity; zinc ion binding
GO_process: intracellular signaling cascade; regulation of Rho protein signal transduction
RefSeq accession NP_003362
SwissProt accession P52735
Substrate protein
Gene name SH3BP2( Description: SH3-domain binding protein 2. )
Synonyms 3BP2; CRBM; CRPM; FLJ42079; RES4-23
GO annotations GO_component:
GO_function:SH3/SH2 adaptor activity [PMID 9299232]
GO_process: intracellular signaling cascade
RefSeq accession NP_003014
SwissProt accession P78314
GO Pathway:
GO:0007242     intracellular signaling cascade
Sequence:(RefSeq accession:NP_003014; substrate region highlighted if known)
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MAAEEMHWPV PMKAIGAQNL LTMPGGVAKA GYLHKKGGTQ LQLLKWPLRF VIIHKRCVYY
FKSSTSASPQ GAFSLSGYNR VMRAAEETTS NNVFPFKIIH ISKKHRTWFF SASSEEERKS
WMALLRREIG HFHEKKDLPL DTSDSSSDTD SFYGAVERPV DISLSPYPTD NEDYEHDDED
DSYLEPDSPE PGRLEDALMH PPAYPPPPVP TPRKPAFSDM PRAHSFTSKG PGPLLPPPPP
KHGLPDVGLA AEDSKRDPLC PRRAEPCPRV PATPRRMSDP PLSTMPTAPG LRKPPCFRES
ASPSPEPWTP GHGACSTSSA AIMATATSRN CDKLKSFHLS PRGPPTSEPP PVPANKPKFL
KIAEEDPPRE AAMPGLFVPP VAPRPPALKL PVPEAMARPA VLPRPEKPQL PHLQRSPLDG
QSFRSFSFEK PRQPSQADTG GDDSDEDYEK VPLPNSVFVN TTESCEVERL FKATSPRGEP
QDGLYCIRNS STKSGKVLVV WDETSNKVRN YRIFEKDSKF YLEGEVLFVS VGSMVEHYHT
HVLPSHQSLL LRHPYGYTGP R
Records:
Category Evidence Reference
A Peptide library Jevremovic D, Billadeau DD, Schoon RA, Dick CJ, Leibson PJ., Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2, [11390470]
A Mutagenesis Jevremovic D, Billadeau DD, Schoon RA, Dick CJ, Leibson PJ., Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2, [11390470]
End of Record Details