ul_7508----
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PPBD protein
Gene name BTRC( Description: beta-transducin repeat containing. )
Synonyms BETA-TRCP; E3RSIkappaB; F-box and WD repeats protein beta-TrCP; FBW1A; FBXW1A; FWD1; MGC4643; bTrCP; bTrCP1; betaTrCP; pIkappaBalpha-E3 receptor subunit
GO annotations GO_component: endoplasmic reticulum
GO_function:ligase activity; protein binding [PMID 9859996]; ubiquitin conjugating enzyme activity [PMID 9990853]
GO_process: signal transduction [PMID 9990853]; ubiquitin cycle; ubiquitin-dependent protein catabolism [PMID 9990853]; Wnt receptor signaling pathway
RefSeq accession NP_003930
SwissProt accession Q9Y297
Substrate protein
Gene name vpu( Description: Vpu. )
Synonyms U ORF protein; Viral protein U
GO annotations GO_component:
GO_function:
GO_process:
RefSeq accession NP_057855
SwissProt accession P05949
Sequence:(RefSeq accession:NP_057855; substrate region highlighted if known)
1
61
MQPIPIVAIV ALVVAIIIAI VVWSIVIIEY RKILRQRKID RLIDRLIERA EDSGNESEGE
ISALVEMGVE MGHHAPWDVD DL
Records:
Category Evidence Reference
A Mutagenesis Margottin F, Bour SP, Durand H, Selig L, Benichou S, Richard V, Thomas D, Strebel K, Benarous R., A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif., [9660940]
End of Record Details