ul_7512----
Record details: Hide
PPBD protein
Gene name BTRC( Description: beta-transducin repeat containing. )
Synonyms BETA-TRCP; E3RSIkappaB; F-box and WD repeats protein beta-TrCP; FBW1A; FBXW1A; FWD1; MGC4643; bTrCP; bTrCP1; betaTrCP; pIkappaBalpha-E3 receptor subunit
GO annotations GO_component: endoplasmic reticulum
GO_function:ligase activity; protein binding [PMID 9859996]; ubiquitin conjugating enzyme activity [PMID 9990853]
GO_process: signal transduction [PMID 9990853]; ubiquitin cycle; ubiquitin-dependent protein catabolism [PMID 9990853]; Wnt receptor signaling pathway
RefSeq accession NP_003930
SwissProt accession Q9Y297
Substrate protein
Gene name NFKBIB
Synonyms I-kappa-B-beta; IKB-B; IKB-beta; IkappaBbeta; NF-kappa-BIB; TR-interacting protein 9; TRIP-9; Thyroid receptor-interacting protein 9
GO annotations GO_component: nucleus
GO_function:protein binding [PMID 14743216]; receptor activity; signal transducer activity [PMID 7776974]; transcription coactivator activity [PMID 7776974]
GO_process: signal transduction [PMID 7776974]; transcription [PMID 7776974]
RefSeq accession NP_002494
SwissProt accession Q15653
Sequence:(RefSeq accession:NP_002494; substrate region highlighted if known)
1
61
121
181
241
301
MAGVACLGKA ADADEWCDSG LGSLGPDAAA PGGPGLGAEL GPGLSWAPLV FGYVTEDGDT
ALHLAVIHQH EPFLDFLLGF SAGTEYMDLQ NDLGQTALHL AAILGETSTV EKLYAAGAGL
CVAERRGHTA LHLACRVGAH ACARALLQPR PRRPREAPDT YLAQGPDRTP DTNHTPVALY
PDSDLEKEEE ESEEDWKLQL EAENYEGHTP LHVAVIHKDV EMVRLLRDAG ADLDKPEPTC
GRSPLHLAVE AQAADVLELL LRAGANPAAR MYGGRTPLGS AMLRPNPILA RLLRAHGAPE
PEGEDEKSGP CSSSSDSDSG DEGDEYDDIV VHSSRSQTRL PPTPASKPLP DDPRPV
Records:
Category Evidence Reference
A Mutagenesis Wu C, Ghosh S., beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta., [10514424]
End of Record Details