ul_7515----
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PPBD protein
Gene name BTRC( Description: beta-transducin repeat containing. )
Synonyms BETA-TRCP; E3RSIkappaB; F-box and WD repeats protein beta-TrCP; FBW1A; FBXW1A; FWD1; MGC4643; bTrCP; bTrCP1; betaTrCP; pIkappaBalpha-E3 receptor subunit
GO annotations GO_component: endoplasmic reticulum
GO_function:ligase activity; protein binding [PMID 9859996]; ubiquitin conjugating enzyme activity [PMID 9990853]
GO_process: signal transduction [PMID 9990853]; ubiquitin cycle; ubiquitin-dependent protein catabolism [PMID 9990853]; Wnt receptor signaling pathway
RefSeq accession NP_003930
SwissProt accession Q9Y297
Substrate protein
Gene name ATF4( Description: activating transcription factor 4 (tax-responsive enhancer element B67). )
Synonyms Activating transcription factor 4; CREB-2; CREB2; Cyclic AMP response element-binding protein 2; DNA-binding protein TAXREB67; TAXREB67; TXREB
GO annotations GO_component: cytoplasm; nucleus
GO_function:protein dimerization activity; sequence-specific DNA binding; specific RNA polymerase II transcription factor activity; transcription factor activity [PMID 12689582]; transcriptional activator activity [PMID 9190894] [PMID 11960987]
GO_process: amino acid metabolism [PMID 12689582]; gluconeogenesis; positive regulation of transcription from RNA polymerase II promoter [PMID 15788408]; regulation of transcription, DNA-dependent; response to stress [PMID 15314157]; transcription
RefSeq accession NP_877962
SwissProt accession P18848
Sequence:(RefSeq accession:NP_877962; substrate region highlighted if known)
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MTEMSFLSSE VLVGDLMSPF DQSGLGAEES LGLLDDYLEV AKHFKPHGFS SDKAKAGSSE
WLAVDGLVSP SNNSKEDAFS GTDWMLEKMD LKEFDLDALL GIDDLETMPD DLLTTLDDTC
DLFAPLVQET NKQPPQTVNP IGHLPESLTK PDQVAPFTFL QPLPLSPGVL SSTPDHSFSL
ELGSEVDITE GDRKPDYTAY VAMIPQCIKE EDTPSDNDSG ICMSPESYLG SPQHSPSTRG
SPNRSLPSPG VLCGSARPKP YDPPGEKMVA AKVKGEKLDK KLKKMEQNKT AATRYRQKKR
AEQEALTGEC KELEKKNEAL KERADSLAKE IQYLKDLIEE VRKARGKKRV P
Records:
Category Evidence Reference
A Mutagenesis Lassot I, Ségéral E, Berlioz-Torrent C, Durand H, Groussin L, Hai T, Benarous R, Margottin-Goguet F., ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase., [11238952]
End of Record Details