ul_7529----
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PPBD protein
Gene name BTRC( Description: beta-transducin repeat containing. )
Synonyms BETA-TRCP; E3RSIkappaB; F-box and WD repeats protein beta-TrCP; FBW1A; FBXW1A; FWD1; MGC4643; bTrCP; bTrCP1; betaTrCP; pIkappaBalpha-E3 receptor subunit
GO annotations GO_component: endoplasmic reticulum
GO_function:ligase activity; protein binding [PMID 9859996]; ubiquitin conjugating enzyme activity [PMID 9990853]
GO_process: signal transduction [PMID 9990853]; ubiquitin cycle; ubiquitin-dependent protein catabolism [PMID 9990853]; Wnt receptor signaling pathway
RefSeq accession NP_003930
SwissProt accession Q9Y297
Substrate protein
Gene name UBE2R2
Synonyms E2-CDC34B; EC 6.3.2.19; Ubiquitin carrier protein R2; Ubiquitin-protein ligase R2
GO annotations GO_component:
GO_function:ligase activity; ubiquitin-protein ligase activity
GO_process: ubiquitin cycle
RefSeq accession NP_060281
SwissProt accession Q712K3
Sequence:(RefSeq accession:NP_060281; substrate region highlighted if known)
1
61
121
181
MAQQQMTSSQ KALMLELKSL QEEPVEGFRI TLVDESDLYN WEVAIFGPPN TLYEGGYFKA
HIKFPIDYPY SPPTFRFLTK MWHPNIYENG DVCISILHPP VDDPQSGELP SERWNPTQNV
RTILLSVISL LNEPNTFSPA NVDASVMFRK WRDSKGKDKE YAEIIRKQVS ATKAEAEKDG
VKVPTTLAEY CIKTKVPSND NSSDLLYDDL YDDDIDDEDE EEEDADCYDD DDSGNEES
Records:
Category Evidence Reference
A Inference Semplici F, Meggio F, Pinna LA, Oliviero S., CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation., [12037680]
End of Record Details