ul_77----
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PPBD protein
Gene name SFN( Description: stratifin. )
Synonyms Epithelial cell marker protein 1; Stratifin; YWHAS
GO annotations GO_component: cytoplasm [PMID 10767298]; extracellular space [PMID 8515476]
GO_function:protein domain specific binding; protein kinase C inhibitor activity [PMID 8515476]
GO_process: cell proliferation [PMID 10767298]; negative regulation of protein kinase activity [PMID 8515476]; regulation of progression through cell cycle [PMID 10767298]; signal transduction [PMID 8515476]
RefSeq accession NP_006133
SwissProt accession P31947
Substrate protein
Gene name MDM4( Description: Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse). )
Synonyms DKFZp781B1423; Double minute 4 protein; MDMX; MGC132766; MRP1; Mdm2-like p53-binding protein; Mdmx protein; p53-binding protein Mdm4
GO annotations GO_component: intracellular; nucleus [PMID 9226370]
GO_function:metal ion binding; protein binding [PMID 10469568] [PMID 10608892]; zinc ion binding [PMID 10608892]
GO_process: apoptosis [PMID 14660608]; cell proliferation [PMID 12101245]; G0 to G1 transition [PMID 12101245]; negative regulation of cell proliferation [PMID 9226370]; negative regulation of protein catabolism [PMID 10608892]; negative regulation of transcription from RNA polymerase II promoter [PMID 9226370]; protein complex assembly [PMID 10608892]; protein stabilization [PMID 10608892]
RefSeq accession NP_002384
SwissProt accession O15151
Sequence:(RefSeq accession:NP_002384; substrate region highlighted if known)
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MTSFSTSAQC STSDSACRIS PGQINQVRPK LPLLKILHAA GAQGEMFTVK EVMHYLGQYI
MVKQLYDQQE QHMVYCGGDL LGELLGRQSF SVKDPSPLYD MLRKNLVTLA TATTDAAQTL
ALAQDHSMDI PSQDQLKQSA EESSTSRKRT TEDDIPTLPT SEHKCIHSRE DEDLIENLAQ
DETSRLDLGF EEWDVAGLPW WFLGNLRSNY TPRSNGSTDL QTNQDVGTAI VSDTTDDLWF
LNESVSEQLG VGIKVEAADT EQTSEEVGKV SDKKVIEVGK NDDLEDSKSL SDDTDVEVTS
EDEWQCTECK KFNSPSKRYC FRCWALRKDW YSDCSKLTHS LSTSDITAIP EKENEGNDVP
DCRRTISAPV VRPKDAYIKK ENSKLFDPCN SVEFLDLAHS SESQETISSM GEQLDNLSEQ
RTDTENMEDC QNLLKPCSLC EKRPRDGNII HGRTGHLVTC FHCARRLKKA GASCPICKKE
IQLVIKVFIA
Records:
Category Evidence Reference
A Inference LeBron C, Chen L, Gilkes DM, Chen J., Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3., [16511560]
End of Record Details